A Roadmap of CAR-T-Cell Therapy in Glioblastoma: Challenges and Future Perspectives
www.mdpi.com
April 27, 2024, 3:25 p.m.
GBM constitutes an aggressive tumor associated with a dismal prognosis. Consequently, a compelling imperative exists for exploring innovative therapeutic interventions. CAR-T-cell therapy has garnered substantial attention within the realm of immunotherapy, showcasing promise across various tumor types, including GBM. Over time, refinements in the structures and functionalities of CAR-T cells have been pursued to enhance their efficacy in targeting tumor antigens. Nevertheless, the formidable challenges posed by the immunosuppressive TME, inter- and intra-tumoral heterogeneity, the immune-privileged status of the brain, and the hypoxic conditions prevailing in the tumor environment present formidable hurdles in the development of efficacious CAR-T-cell therapies for GBM.