Researchers found that CUX2 neurons are especially sensitive to damage caused by inflammation. In diseases like MS, the body’s immune system attacks the brain, leading to long-term damage. While MS has been thought to primarily affect white matter in the brain, this research shows that it could also damage particularly vulnerable CUX2 neurons in the gray matter.This damage may help explain why people with MS can experience memory problems and cognitive decline as the disease progresses.“The CUX2 neurons are like a ‘canary in the coal mine’ for the brain affected by MS,” said David Rowitch, MD, PhD, co-corresponding author of both studies, deputy director for Research at Guerin Children’s, and professor of Paediatrics at the University of Cambridge. “They are early warning signs of trouble. If we can protect these cells, we might be able to contain the damage before disease progresses.”

For years, scientists have suspected that the gut plays a role in Multiple Sclerosis (MS), but the “smoking gun” linking the two has been elusive. A landmark study has finally identified the cellular mechanism: Intestinal Epithelial Cells (IECs)—the cells lining your gut—are acting as “accidental” messengers.The study found that in patients with MS, these gut cells abnormally express MHC II, a protein that “presents” antigens to the immune system. This interaction mistakenly transforms ordinary immune cells into pathogenic Th17 cells, which then migrate from the gut directly to the central nervous system to attack the brain and spinal cord.

Researchers from UC San Francisco, the University of Cambridge, and Cedars-Sinai Medical Center now report that this loss is linked to DNA damage inside neurons, driven by inflammation in the brain. The discovery helps explain why scans of people with MS show injury not only in white matter, which carries signals, but also in gray matter, where brain cells reside. It also points to new treatment possibilities.

A gene on the X chromosome revs up inflammation in the female brain, which may explain why rates of multiple sclerosis are higher in women than in men, scientists suggest.

Progressive multiple sclerosis (PMS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) characterized by relentless progression and limited treatment options. Recent studies have highlighted the role of B cells and plasma cells in driving PMS but current therapies face challenges in targeting cells within the CNS. Now, writing in Cell, Qin et al. present a first-in-human study of anti-B cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy in five patients with PMS, showing a favourable safety profile and potential therapeutic benefits.

Près de deux millions de personnes dans le monde souffrent de cette maladie invalidante. Les symptômes varient énormément, et il n'y a aucun remède connu à ce jour.

Pendant des décennies, les scientifiques ont accumulé des indices pointant vers le virus Epstein-Barr. Présent dans l’organisme de plus de 90% des adultes à travers le monde, ce virus de la famille des herpès est connu pour provoquer la mononucléose infectieuse. Or, plusieurs études avaient déjà observé une surreprésentation de cette infection dans les antécédents des patients atteints de sclérose en plaques. La corrélation intrigue, mais reste difficile à interpréter tant le virus circule largement dans la population générale.

Multiple sclerosis (MS) is among the most common causes of disability in the young and, despite the advent of highly effective disease-modifying therapies, remains an incurable disease. Prevention of MS before the onset of demyelination is a feasible, albeit ambitious, goal. Currently, preventive interventions with adequate evidence of efficacy are lacking, and evaluating such interventions with traditional trial designs is challenging. Additionally, the high frequency and low effect sizes of putative MS risk factors, a limited window of opportunity to intervene, and the relatively low incidence of MS in the general population make prevention studies conceptually and practically difficult.

While MS is a chronic condition, its progression isn't uniform or predictable. Some people experience minimal progression over many years, while others may face more rapid changes. Let's explore the factors that influence MS progression and what current research tells us about managing the condition.

Multiple sclerosis (MS) stands out as one of the most prevalent causes of disability among young adults, placing immense pressure on healthcare systems and affecting the quality of life for those affected. Despite advancements in therapies that modify the course of the disease, MS has yet to be declared curable. This presents an ongoing challenge for researchers and clinicians alike. The focus is now shifting toward the ambitious—but indeed feasible—goal of preventing MS before any symptoms or demyelination occur. However, the path to achieving this presents numerous methodological challenges that call for innovative thinking.

MS is a chronic autoimmune disease affecting the CNS over a long-term period. The severity of MS varies widely and is influenced by several factors, comprising the endocrine activity of AT. The involvement of AT in MS pathogenesis remains to be further clarified; certainly, MS is characterized by an altered immune response in which AT also participates through dysregulated adipokine secretion, increasing the risk of disease development and accelerating its progression. Based on the data presented in this review, it is plausible that the functionality of AT is positively influenced by lifestyle factors such as physical activity and nutrition, which are essential in the management of MS.

Researchers revealed a pivotal mechanism in myelin repair and regeneration, focusing on the Daam2 protein and CK2α kinase. Myelin, critical for efficient neurotransmission, when damaged leads to serious neurological diseases. Their findings spotlight the Wingless (Wnt) signaling pathway, crucial for myelin regeneration. Unveiling how Daam2 inhibits myelination, this study offers hope for untreatable neurological conditions.

Pour la première fois, un élément crucial de la progression de la maladie vient d'être mis au jour : le premier variant génétique associé à une sévérité accrue de la sclérose en plaques. Dans l'ADN, les variants sont des changements permanents sur les gènes. On les appelle des "polymorphismes" lorsque ces changements sont fréquents dans la population ou des "mutations" lorsque le changement est rare. Peu importe leur nature, les variants, de par les modifications qu'ils entraînent dans l'ADN, peuvent être à l'origine de maladies.

Alors que la sclérose en plaques demeure aujourd’hui incurable, une équipe de neuroscientifiques de l’Université de Virginie a fait une découverte majeure, qui pourrait changer la vie des malades. Ils ont en effet identifié le récepteur cellulaire qui provoque la réponse auto-immune et la neuroinflammation caractéristiques de la maladie. Il pourrait s’agir d’une nouvelle cible de choix pour la mise au point de nouveaux traitements.

La progression de cette maladie du système nerveux central peut être freinée grâce une transplantation de cellules souches sanguines, avec environ 80 % d'efficacité. Pourtant, ce traitement reste négligé en France. Ses détracteurs pointent la lourdeur du dispositif et son coût. Explications.

A recent study offers the strongest evidence yet of the link between the Epstein-Barr virus and MS. Not everyone is convinced.

Consistent with the incubation studies, the mouse pharmacokinetic study demonstrated that alcohol decreased the maximum concentration and area-under-the-curve of MMF in the plasma and the brain after dosing with DMF. We conclude that alcohol may markedly decrease exposure to the active MMF metabolite in the plasma and brain potentially decreasing the effectiveness of DMF in the treatment of RRMS.

Brainomix will distribute Neuro.MS, Pixyl’s Software as a Service (SaaS) solution for diagnosis and treatment of patients with multiple sclerosis (MS), exclusively in the UK and Ireland, the Nordics and key markets across Eastern Europe

A little under 10 years ago, Leigh Krauss was almost done with her schooling to become a physical therapist. A former guard on the women’s basketball team at Trinity College in Hartford, Conn., she had always been active and healthy. That is, until one day, walking to class, she lost vision in one eye. Krauss was soon diagnosed with multiple sclerosis, a chronic autoimmune disease where nervous system glitches cause a disconnect between the brain and the body.

Everyone knows that the brain is the command center of the body. This organ is part of the central nervous system that works with the spinal cord and the vital organ systems to send signals that provide motor-sensory functions to make the body do everyday movements. The signals from the brain have a casual relationship with the immune system. When environmental factors enter the body, the brain signals the immune system to send inflammatory cytokines to the area where it was affected and begin the body’s healing process. The immune system helps clean up the body’s cellular structure by replacing old, damaged cells with new, healthy cells. However, when the immune system starts to attack specific parts of the body mistakenly, it can damage the healthy cells causing autoimmune diseases to develop in the body.