Tattoos can induce bloodstream infections Aug. 29, 2022, 9:12 a.m.
Tattooing is a painful process that involves the introduction of artificial pigment under the skin. If not performed hygienically, tattoos can induce various health complications, including immune and inflammatory reactions, infections, and chronic skin defects such as dermatoses. Between 2% and 27% of individuals experience some sort of discomfort after having a tattoo, with 0.5-6% developing skin infections.
Free webinar on microneedles for medical applications July 18, 2022, 10:31 a.m.
Live webinar on 3D Microfabrication of microneedles for medical applications using rapid prototyping and direct 3D printing for series production. Register now
Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer July 3, 2022, 3:24 p.m.
Photodynamic therapy (PDT) to manage non-melanoma skin cancers has garnered great attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with promising anticancer therapeutic activities. Nevertheless, its poor water-solubility, aggregation in biological systems and insufficient skin penetration restricted its effective exploitation. Herein, we report for the first-time encapsulation of Hy into lipid nanocapsules (Hy-LNCs), and then application of an AdminPen™ hollow microneedles (Ho-MNs) array and an in-house fabricated Ho-MN to enable efficient intradermal delivery.
A Painless, Micro Injection that One Can Do Oneself with the Latest Chula's Innovation "Detachable and Dissolvable Microneedles" July 3, 2022, 3:23 p.m.
A startup under the umbrella of CU Innovation Hub in collaboration with the Chula Faculty of Science has developed an innovative “Detachable and Dissolvable Microneedle” that makes any injections easy and painless for everyone, while also significantly reducing medical wastes.
Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications July 3, 2022, 3:22 p.m.
Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made significant changes in fabrication techniques for microneedles (MNs) and design shifted from conventional to novel, using various types of natural and synthetic materials and their combinations. Nowadays, MNs technology has gained popularity worldwide in biomedical research and drug delivery technology due to its multifaceted and broad-spectrum applications. This review broadly discusses MN’s types, fabrication methods, composition, characterization, applications, recent advancements, and global intellectual scenarios.
Self-plugging microneedle for drug delivery July 3, 2022, 3:20 p.m.
A collaborative team, including scientists from the Terasaki Institute for Biomedical Innovation (TIBI), has developed a novel microneedle for injecting therapeutics into the eyes, potentially solving one of the major challenges of treating eye diseases – accurate delivery of therapeutic drugs to the retina, while guarding against possible complications at the injection site.
Research progress of microneedles in the treatment of melanoma July 3, 2022, 3:13 p.m.
As an emerging drug delivery system, microneedles (MNs) can efficiently deliver drugs through the skin, increase the drug distribution in deeper tumor sites and minimize the leakage of therapeutic drugs into adjacent tissues, thus improving the therapeutic effect. In addition, compared with traditional drug delivery methods, MN-based drug delivery system has the advantages of simplicity, safety and little pain.
The start-ups taking nanoneedles into the clinic July 3, 2022, 2:30 p.m.
Nanoneedle start-ups are traversing the biotech valley of death — from fundamental university research into commercial development in advanced therapeutics and diagnostics. How can academics make the most of this opportunity?
Dissolving undercut microneedle arrays for multicomponent cutaneous vaccination May 22, 2022, 10:27 a.m.
Cutaneous vaccination of mice using these MNAs induces more potent antigen-specific cellular and humoral immune responses than those elicited by traditional intramuscular injection. Together, the unique geometric features of these undercut MNAs and the associated manufacturing strategy, which is compatible with diverse drugs and biologics, could enable a broad range of non-cutaneous and cutaneous drug delivery applications, including multicomponent vaccination.
Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern April 10, 2022, 6:45 p.m.
In this study, a modified, HexaPro S protein subunit vaccine, delivered using a needle-free high-density microarray patch (HD-MAP), was investigated for its immunogenicity and virus-neutralizing abilities. Mice given two doses of the vaccine candidate generated potent antibody responses capable of neutralizing the parental SARS-CoV-2 virus as well as the variants of concern, Alpha and Delta. These results demonstrate that this alternative vaccination strategy has the potential to mitigate the effect of emerging viral variants.
Localised light delivery on melanoma cells using optical microneedles Feb. 9, 2022, 1:23 p.m.
Light-based therapy is an emerging treatment for skin cancer, which has received increased attention due to its drug-free and non-invasive approach. However, the limitation of current light therapy methods is the inability for light to penetrate the skin and reach deep lesions. As such, we have developed a polylactic acid (PLA) microneedles array as a novel light transmission platform to perform in vitro evaluation regarding the effect of light therapy on skin cancer. For the first time, we designed and fabricated a microneedle array system with a height fixation device that can be installed in a cell culture dish and an LED array for blue light irradiation. The effect of the blue light combined with the microneedles on cell apoptosis was evaluated using B16F10 melanoma cells and analyzed by Hoechst staining. Our results demonstrate that blue light can be transmitted by microneedles to skin cells and effectively affect cell viability
Skin co-delivery of contact sensitizers and neurokinin-1 receptor antagonists integrated in microneedle arrays suppresses allergic contact dermatitis Feb. 9, 2022, 12:54 p.m.
Our findings demonstrate that immune-regulation by engineering localized skin neuroimmune networks can be used to treat cutaneous diseases that like CD, are caused by type-1 immunity.
Painless drug delivery via melting ice microneedle patches Feb. 9, 2022, 12:49 p.m.
Experiments using this groundbreaking invention on mice with cancers have shown that the animals’ immune responses were much better than those seen in conventional vaccination methods. The technology paves the way for developing an easy-to-use cell therapy and other therapeutics against cancers and other diseases. Made from a cryogenic solution, these icy microneedles are less than 1mm long and can deliver living mammalian cells into the skin. The device is like a skin patch and the microneedles can detach from the patch base, melt and then penetrate the skin.
Clinical trial of needle-free COVID-19 vaccine underway in Australia June 7, 2021, 4:36 p.m.
Researchers and biotechnology company Vaxxas are studying if the new delivery technology, called a high-density microarray patch, can protect participants from diseases including measles and rubella. If successful, the needle-less technology could be used for a number of other vaccinations including influenza and COVID-19.
Recent progress in silk fibroin-based flexible electronics May 15, 2021, 2:32 p.m.
Silk fibroin has been widely used as fundamental components for the construction of biocompatible flexible electronics, particularly for wearable and implantable devices. Furthermore, in recent years, more attention has been paid to the investigation of the functional characteristics of silk fibroin, such as the dielectric properties, piezoelectric properties, strong ability to lose electrons, and sensitivity to environmental variables. Here, this paper not only reviews the preparation technologies for various forms of silk fibroin and the recent progress in the use of silk fibroin as a fundamental material but also focuses on the recent advanced works in which silk fibroin serves as functional components. Additionally, the challenges and future development of silk fibroin-based flexible electronics are summarized.
Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis March 24, 2021, 7:08 p.m.
A need-based layered dissolving microneedle system loading tacrolimus (TAC) and diclofenac sodium (DIC) in different layers specifically delivers TAC and DIC to skin and articular cavity, simultaneously alleviating psoriatic skin and arthritic joint lesions.
Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis March 15, 2021, 10:19 a.m.
Conclusion. Acupuncture is an effective and safe treatment for CPRD, and acupuncture combined with drug therapy is more effective than single-drug therapy. Nevertheless, the conclusions were limited due to the low quality and a small number of included studies.
3D-printed microneedles in biomedical applications Feb. 15, 2021, 1:48 p.m.
3D printing offers customization, cost-efficiency, a rapid turnaround time between design iterations, and enhanced accessibility. Increasing the printing resolution, the accuracy of the features, and the accessibility of low-cost raw printing materials have empowered 3D printing to be utilized for the fabrication of microneedle platforms. The development of 3D-printed microneedles has enabled the evolution of pain-free controlled release drug delivery systems, devices for extracting fluids from the cutaneous tissue, biosignal acquisition, and point-of-care diagnostic devices in personalized medicine.
Nearly pain-free microneedle patch can test for antibodies and more in the fluid between cells Feb. 8, 2021, 6:48 p.m.
Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19; or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and sepsis.
Researchers 3D print hollow microneedles for controlled transdermal drug delivery Jan. 21, 2021, 7:56 a.m.
Researchers from the University of Kent and the University of Strathclyde have developed a novel device that combines 3D printing, microneedles, and microelectromechanical systems (MEMS) for controllable transdermal drug delivery.