These findings suggest that low LDL-C levels are associated with an increased bleeding risk within 3 months among patients with minor ischemic stroke or high-risk transient ischemic attack who are receiving dual antiplatelet therapy, especially those taking ticagrelor-aspirin.

Deployed in the correct manner, future BCIs have the potential to enable their users to control computers with their thoughts after loss of function. This could be life-changing for millions of patients with conditions such as locked-in syndrome, amyotrophic lateral sclerosis (ALS), or tetraplegia. Clinical research and testing of devices for various conditionsopens in a new tab or window is ongoing, and several companiesopens in a new tab or window have made significant stridesopens in a new tab or window to bring these devicesopens in a new tab or window toward commercialization and reaching patients.

The preliminary findings confirmed the proposed smart stent's higher level of structural integrity, durability and repeatability. Finally, the practical feasibility of the smart stent is demonstrated by monitoring diastole and systole at various beat rates using a phantom. The results of the phantom study showed a similar pattern to the human model, indicating the potential use of the proposed multifunctional smart stent for real-time applications.

The interaction of biomaterials with blood leads to cellular as well as humoral reactions, which can result in an unwanted inflammation and activation of coagulation and/or fibrinolysis. Thus, the development of biomaterials with an improved hemocompatibility increases the tolerability and minimizes unwanted side effects, such as thrombus formation. Therefore, during the development of new blood-contacting medical devices, not only the mechanical and chemical characteristics should play an important role, but also the hemocompatibility. Furthermore, to prove the safety and reliability of new products, hemocompatibility analyses should include appropriate references and follow the ISO 10993-4 standard.

There is currently no standardized test method for in vitro dynamic thrombogenicity assessment of medical devices and biomaterials. This tool will effectively enable users to differentiate device materials with different thrombogenic potentials against standard negative and positive control materials and a marketed comparator device with known thrombogenicity profile.

These results demonstrated that multiple animal blood sources (particularly donor ovine and bovine blood) may be suitable alternatives to fresh human blood for dynamic thrombogenicity testing when appropriate control materials and donor-specific anticoagulation levels are used.

To evaluate the use of the large language models (LLMs) GPT-4 and GPT-3.5 to extract data from neuroradiology reports on mechanical thrombectomy in patients with ischemic stroke.

Since February 2005 when NMPA (then CFDA) published the first batch of medical device clinical sites, a total of 1380 hospitals became certified to conduct clinical research in China as of April 2024. All 1380 sites have different clinical specialties registered with NMPA. We can help you select the right hospital and save time for market introduction.

In ICAS surgical treatment, when the anterior-posterior diameter difference of the diseased vessel is found to be small and the vessel segment is relatively straight, we can effectively utilize the NOVA® Intracranial Drug-Eluting Stent with the intermediate catheter in place. The use of the NOVA® Intracranial Drug Eluting Stent can significantly simplify the surgical process, reduce the difficulty of the operation, and thus effectively minimize the complications that may arise during the operation. This strategy not only improves the safety of the operation, but also enhances the patient's recovery

In the US between 1990 and 2019, age-standardized stroke rates have decreased, however, the rates of absolute burden and hemorrhagic stroke have increased.

In this prospective, single-arm study, SAC embolization of unruptured distal ICA aneurysms using the modified Alpha stent has exhibited excellent results regarding safety and efficacy. However, radiologic follow-up by TOF-MRA demonstrated suboptimal visualization of in-stent flow. Further studies on its use in various locations with long-term clinical and radiological data are necessary.

Replacing aspirin with indobufen in the dual antiplatelet (DAPT) regimen for patients without elevated cardiac troponin after successful drug-eluting stent implantation results in a lower risk of 1-year net clinical outcomes, a difference driven by nonserious bleeding events, according to the randomized OPTION trial.

Stents are usually placed in the carotid arteries, which are the main arteries that supply blood to the brain. When the carotid arteries become narrowed, there is a risk of stroke due to the reduced blood supply. Intracranial stenosis stents help restore normal blood flow to the brain by opening up the narrowed artery.

This review highlights the crucial role that clinical imaging plays in unraveling the complex molecular mechanisms that underlie ischemic stroke. Techniques such as CT, MRI, and fluorescence imaging provide invaluable insights into the progression of stroke and the identification of potential therapeutic targets. Moreover, the advancements in radiopharmaceuticals and experimental models offer promising avenues for further exploration. By integrating molecular events with imaging modalities, this interdisciplinary approach enhances our understanding of ischemic stroke and holds significant implications for future research and clinical interventions. Ultimately, this approach aims to improve patient outcomes in this debilitating condition.

Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes of death and disability worldwide. Thus, it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the disease. In recent years, efforts have been made to understand the pathophysiology of ischemic stroke, including cellular excitotoxicity, oxidative stress, cell death processes, and neuroinflammation. In the meantime, a plethora of signaling pathways, either detrimental or neuroprotective, are also highly involved in the forementioned pathophysiology. These pathways are closely intertwined and form a complex signaling network.

The world's first self-expanding intracranial drug-coated stent system, called COMETIU™, complements the NOVA® Intracranial Drug-Eluting Stent System with its safety and non-neurotoxicity, reduced risk of in-stent restenosis and stroke recurrence, improved procedural safety in the area of the richly branched stent, access to the tortuous vessels, and ease of operation.

The introduction of endovascular thrombectomy dramatically changed acute stroke management and became the standard treatment. Balloon guide catheters provide flow arrest during the clot retrieval process and have several advantages.This study aimed to compare balloon guide catheters (BGCs) versus non-balloon guide catheters (NBGCs) as a part of a combined treatment modality in patients presenting with acute ischemic stroke.

Hypoxic-ischemic brain injury arises from inadequate oxygen delivery to the brain, commonly occurring following cardiac arrest, which lacks effective treatments. Recent studies have demonstrated the therapeutic potential of exosomes released from mesenchymal stem cells. Given the challenge of systemic dilution associated with intravenous administration, intranasal delivery has emerged as a promising approach. In this study, we investigate the effects of intranasally administered exosomes in an animal model.

Aspirin nonadherence became more prevalent over time, from 10% at 2 years to 19% at 8 years. The greatest risk for recurrent MI, stroke or death occurred at 2 to 4 years for the adherent and nonadherent groups.

The present study results suggest that direct aspiration is a safe and effective treatment for patients with BAO. We identified several factors affecting the patients