Tadalafil, which has the longest half-life among PDE-5 inhibitors, does not prevent endothelial apoptosis as much as nimodipine, but it still prevents smooth muscle cell proliferation in the tunica media, restores damaged endothelial integrity, increases cerebral blood flow, and is thought to have various neuroprotective functions through the PI3K/AKT/eNOS signaling pathway. We believe that more in-depth research on tadalafil in the future will prove the therapeutic potential of this drug for DCI.

This breakthrough medical device product is the first drug-eluting stent for the treatment of intracranial atherosclerotic stenosis in the history of the U.S. FDA, and it is also the first domestic neurointerventional device product to be recognized as a breakthrough medical device by the U.S. FDA.

AD is independently associated with an increased risk of stroke, especially in men, and there is a notable association with ischemic stroke. Moreover, the risk appears to be positively correlated with the severity of AD.

While clot composition does not significantly affect the success of First Pass Recanalization (FPR), it is significantly associated with the risk of intracranial hemorrhage. This underscores the potential clinical relevance of clot histology in predicting post-thrombectomy outcomes, beyond the well-established importance of FPR itself. Future studies with larger and more diverse patient cohorts are warranted to further elucidate these associations and optimize treatment strategies.

A novel study reveals that targeting a single protein’s aggregation can dramatically reduce brain injury after stroke, potentially transforming how acute ischemic strokes are treated.

This study estimated increases of hospital LOS and costs for patients with severe surgical bleeding complications in France. Hospitalisations longer than the average LOS across all DRGs indicated significant costs associated with severe post-surgical bleeding. Awareness of the clinical and economic consequences of severe post-surgical bleeding provides an important framework when evaluating blood conservation strategies.

Antiplatelet therapy is key to reducing local thrombotic complications and systemic ischaemic events among patients undergoing percutaneous coronary interventions (PCI), but it is inevitably associated with increased bleeding. The continuous refinement in stent technologies, together with the high incidence of ischaemic recurrences after PCI and the understanding of prognostic implications associated with bleeding, have led to a substantial evolution in antiplatelet treatment regimens over the past decades.

CD31 signaling promotes the switching of proinflammatory macrophages to the reparative phenotype and favors the healing of experimental dissected aortas. Treatment with a drug-suitable CD31 agonist may facilitate the clinical management of ADIM.

Clot-induced blockage in arteries or veins can cause severe medical conditions. Mechanical thrombectomy is a minimally invasive technique used to treat ischaemic stroke, myocardial infarction, pulmonary embolism and peripheral vascular disease by removing clots through aspiration, stent retriever or cutting mechanisms. However, current mechanical thrombectomy methods fail to remove clots in 10–30% of patients, especially in the case of large, fibrin-rich clots. These methods can also rupture and fragment clots, causing distal emboli and poor outcomes. To overcome these challenges, we develop the milli-spinner thrombectomy, which uses a simple yet innovative mechanics concept to modify the clot’s microstructure, facilitating its removal.

In past decades, the discovery of stem cells and byproducts has led to promising results in in vitro settings and pre-clinical studies. Extracellular vesicles (EVs) are nano-sized particles released from various cell types, for instance, mesenchymal stem cells (MSCs), with certain signaling biomolecules, growth factors, and cytokines involved in cell-to-cell communication. A great plethora of studies have pointed to the fact that EVs with specific cargo can distribute easily in different parts of the body, making them appropriate therapeutics under different pathological conditions. The current review articles aimed to highlight the neuroangiogenesis properties of MSC EVs in IS conditions. How and by which mechanisms MSC EVs can orchestrate the process of nervous system regeneration is at the center of debate.

AUCURA represents China’s first flow-diverting stent featuring both 0.017-inch system deliverability and an antithrombotic coating. The stent is woven from cobalt-chromium-platinum DFT wire with full-body radiopacity. Its superhydrophilic surface technology reduces contact angle to minimize plasma protein/platelet adhesion, significantly lowering the risk of stent thrombosis. By modifying aneurysm hemodynamics and promoting endothelial healing at the neck region, AUCURA enables effective treatment of intracranial aneurysms.

The AUCURA blood flow-diverter was officially approved by China's National Drug Administration (NMPA). This product is the first dense-mesh stent that can be transported by a 0.017" system, and with an antithrombotic eG NTMA coating, bringing a complete upgrade in the treatment of intracranial aneurysm.

Expanding care to stroke victims is one of medtech’s biggest opportunities, and startup Artedrone is developing a microrobot system that can navigate to blood clots for autonomous mechanical thrombectomies.

The findings demonstrate that heparin coated flow diverter stents are characterized by a lower thrombotic signature than bare metal flow diverter stents and raise the possibility of an additional therapeutic option to treat intracranial aneurysms.

Despite the continual progress in technology, thromboembolic complications still occur following endovascular treatment of cerebral aneurysms and remain the primary contributor to morbidity and mortality. Thus, coating the surfaces of blood-contacting flow diverters may reduce thrombus-related complications in clinical use. In this study, the hemocompatibility of different commercially available flow diverters Pipeline Flex Embolization Device with Shield Technology (Medtronic), the p64 MW HPC (Phenox), and the DERIVO 2heal (Acandis) was investigated using an in vitro blood circulation model.

While stroke treatment has dramatically changed in recent years, still around 795,000 people experience a new or recurrent stroke each year, and of all strokes 87% are ischaemic.1 A high variability in accessing stroke treatments exists across different countries or different regions within the same nation, even if at present guidelines are quite definitive in indicating endovenous thrombolysis and mechanical thrombectomy (MT) in selected cases as key treatment points. However, treatment indications are continuously evolving and so the vascular surgery world should be prepared to evolve accordingly.

Stryker notes that the Artix system builds on the success of Inari’s venous thrombectomy devices and is its inaugural entry into the arterial space. “Inari offers a comprehensive toolkit approach to arterial thrombectomy with an innovative, over-the-wire system that provides physicians with the flexibility to aspirate and/or mechanically extract a clot,” a press release reads.

The study assessed the working status of Norwegian patients with untreated unruptured intracranial aneurysms (UIAs) from 2008 to 2018. It found that these patients had significantly lower work participation pre- and post-diagnosis compared to the general population, highlighting potential psychological and health burdens.

The researchers found that across all urbanization levels, the age-adjusted ischemic stroke mortality rates increased since 2009; the most pronounced increases were seen in nonmetropolitan areas. There was an increasing proportion of deaths at home, shifting from inpatient medical facilities. There were significant disparities in access to specialized end-of-life stroke care, especially for racial minorities and rural residents. The likelihood of dying in less specialized environments was increased for Black/African American individuals and those in rural settings due to health care access barriers.

Medtronic's Pipeline Vantage embolization device with Shield Technology is used to treat cerebral aneurysms. This endovascular interventional device is implanted into a blood vessel through a minimally invasive catheter to deliver the braided catheter to the aneurysm site to block blood flow.