Ruptured saccular (berry) aneurysms usually result in subarachnoid hemorrhage (SAH) but can, depending on the location of the rupture and presence of adhesions to the aneurysm, also result in cerebral hematoma, subdural hematoma, and/or intraventricular hemorrhage.

PED offers a reasonably safe and effective treatment of large or giant intracranial internal carotid artery aneurysms, demonstrated by high rates of complete aneurysm occlusion and low rates of adverse neurologic events; even in aneurysms failing previous alternative treatments.

Researchers have developed biomimetic hydrogel design strategies to advance the creation of vascular grafts and vascularized tissue constructs. This review, published in Frontiers in Bioengineering and Biotechnology by Tong, Chen, Li, and Zhao, examines how hydrogel materials can mimic natural blood vessel properties to enhance tissue engineering applications. The work focuses on biomimetic materials that promote physiological neovascularization—the natural formation of new blood vessels—within engineered tissue scaffolds. By incorporating design principles from native vascular tissue, these hydrogels aim to improve graft integration, biocompatibility, and functional performance. This research is significant for regenerative medicine, as developing effective vascular grafts remains a critical challenge in treating cardiovascular diseases and tissue reconstruction. The biomimetic approach offers promising potential to create blood vessel prostheses that function more like native tissue, potentially reducing rejection rates and improving long-term clinical outcomes for patients requiring vascular interventions or tissue replacement therapies.

Fenestrated and branched endovascular aneurysm repair (FEVAR/BEVAR) procedures address thoraco-abdominal aortic aneurysms in patients over 60, but surgeons face significant challenges navigating standard catheters through aortic branches to deploy stent grafts while preserving blood flow to vital organs. This work presents a novel solution: a modular, steerable robotic catheter system featuring a two-segment design with four degrees of freedom to enhance surgical dexterity. The catheter was fabricated using thermal fiber drawing, a high-throughput technique for creating high-aspect ratio devices, followed by laser micro-machining to soften the tip. Researchers developed an expandable, tendon-driven actuation platform to manage system redundancies. Evaluation through simulation and in-vitro vascular phantom experiments demonstrated the catheter's bending stiffness and steerability. Given that cardiovascular disease caused 19.8 million deaths globally in 2022, minimally invasive endovascular solutions are critical. This handheld robotic catheter system promises to reduce procedural time, lower complication rates, and enable clinicians to manage complex anatomical cases previously considered challenging.

The DISCOUNT randomized clinical trial evaluated mechanical thrombectomy for ischemic stroke patients with medium or distal arterial occlusions. Conducted by Clarençon and colleagues across European stroke centers, the trial was terminated early after an interim analysis of 163 patients when the independent data safety monitoring board identified concerning findings. Of 261 randomized patients (244 in full analysis), thrombectomy demonstrated numerically lower efficacy than the control treatment, with symptomatic intracranial hemorrhage occurring more frequently in the intervention group and conditional power falling below ten percent. The trial's conclusions represent a significant practice shift, demonstrating that successful rechanalization of smaller distal vessels such as M2/M3, anterior cerebral artery, or posterior cerebral artery occlusions does not justify invasive thrombectomy procedures when functional outcomes remain absent and hemorrhagic risks increase. Alongside companion trials DISTAL and ESCAPE-MeVO, DISCOUNT redirects clinical practice toward selective, phenotype-informed patient selection based on deficit severity, vascular anatomy, imaging characteristics, thrombolysis response, and procedural risk assessment rather than routine vessel-based intervention approaches, particularly in functionally independent older patients with moderate deficits in well-resourced European stroke systems.

Galaxy Therapeutics announced CE Mark approval for its SEAL (saccular endovascular aneurysm lattice) embolization system, a novel device designed for treating ruptured and unruptured wide-neck intracranial aneurysms. The approval, granted under the European Medical Device Regulation 2017/745 following assessment by notified body DQS Medizinprodukte GmbH, enables phased commercial introduction across selected European markets. The SEAL system utilizes an intrasaccular approach to simplify aneurysm treatment across complex anatomies, accommodating aneurysm sizes from 2 to 19 millimeters—a broader range than competing intrasaccular technologies. The approval culminates several years of development, engineering, manufacturing, and clinical investigation, including Galaxy's international clinical programs and the pivotal SEAL IT trial in the United States. Galaxy continues pursuing FDA premarket approval. Chief Medical Officer Michael Alexander emphasized that SEAL addresses significant physician challenges in treating complex intracranial aneurysms and expands treatment options for European patients. The approval represents meaningful progress in expanding therapeutic alternatives for this critical patient population.

A 65-year-old man with hypertension and atrial fibrillation presented to the emergency department approximately 12.5 hours after experiencing falls and slurred speech at home. Clinical examination revealed right middle cerebral artery syndrome with a National Institutes of Health Stroke Scale score of 9, characterized by right gaze preference, left facial droop, mild arm and leg drift, sensory deficits, and dysarthria. Computed tomography imaging identified early ischemic changes in the right middle cerebral artery territory with an Alberta Stroke Program Early Computed Tomography Score of 5, while CT angiography confirmed a distal M1 segment large vessel occlusion. CT perfusion imaging quantified the infarct core at 46 milliliters with 119 milliliters of penumbra. The patient underwent endovascular thrombectomy, achieving Thrombolysis in Cerebral Infarction 2b reperfusion. This case exemplifies current clinical decision-making regarding EVT candidacy in acute ischemic stroke, illustrating how multimodal imaging integrates with clinical presentation to guide intervention strategies and optimize patient outcomes in large vessel occlusion management.

Hemocompatible coatings represent a critical strategic consideration in medical device development, with choices between heparin and non-heparin formulations, short-dwell versus implantable applications, and animal-derived or synthetic materials each carrying distinct clinical, regulatory, and manufacturing implications. Rather than treating coating selection as a final specification, leading companies like Surmodics recognize that early-stage engagement during the feasibility phase is essential. Decisions made during initial development stages directly influence validation approaches, regulatory defensibility, and long-term clinical durability. The optimal coating system for any given device emerges from a structured evaluation of clinical use requirements, intended dwell time, substrate compatibility, and regulatory pathway—an approach that typically yields solutions different from first-considered options. This strategic methodology ensures that coating selection aligns comprehensively with the device's clinical profile and regulatory requirements, ultimately determining successful commercialization and sustained clinical performance.

A multicentre retrospective study published in Radiology demonstrates that the Woven EndoBridge (WEB) intrasaccular flow disruption device, manufactured by Microvention/Terumo, can be safely extended beyond its FDA-approved use in wide-neck bifurcation aneurysms to treat sidewall intracranial aneurysms. Led by Nimer Adeeb and Adam Dmytriw, the WorldWideWEB Consortium analysed 683 intracranial aneurysms across 671 patients treated at 22 academic institutions globally between January 2011 and June 2021. The study compared 91 matched pairs of bifurcation and sidewall aneurysms using propensity score matching. Results revealed no significant differences in deployment success, complication rates, procedure duration, or adjunctive coil use between groups. While sidewall aneurysms achieved higher immediate adequate occlusion rates (66.1% versus 43.3%), long-term outcomes were equivalent (89% versus 85%), with retreatment rates of 10.9% and 7.2% respectively. These findings support expanding WEB device indications to sidewall lesions when location, neck angle, and size are properly characterized.

Cerebral aneurysms, characterized by localized arterial wall dilation in the brain, pose significant risks of rupture and life-threatening hemorrhage. Researchers demonstrated the potential of Magnetic Particle Imaging (MPI) for detecting and monitoring aneurysms and their treatment. Using patient-specific CT-derived artery phantoms containing cerebral aneurysms, the team employed MPI with millisecond temporal resolution to track magnetic nanoparticle (MNP) tracer boluses through vascular structures. They compared flow measurements in untreated aneurysm models with those treated using flow diverter stents, which redirect blood flow away from the aneurysm to promote clot formation and occlusion. MPI's exceptional temporal and spatial resolution enabled detailed hemodynamic analysis and quantification of flow changes before and after stent placement. These findings highlight MPI's promising capabilities for non-invasive assessment of aneurysm status and treatment efficacy, offering valuable insights for future clinical applications in evaluating both untreated and stent-treated cerebral aneurysms in patient populations.

Wide-necked bifurcation aneurysms (WNBAs)—lesions with a neck exceeding 4 mm or an aspect ratio below 1.6—present significant endovascular treatment challenges due to coil prolapse risks and the need to protect two vessels simultaneously. Traditional approaches including balloon-assisted coiling, stent placement, and flow diversion have limitations and increased procedural complexity. Three innovative intrasaccular devices now offer promising alternatives at various approval stages globally: the Woven EndoBridge (WEB) by MicroVention, the Artisse Embolization Device by Medtronic, and the Contour Neurovascular System by Cerus Endovascular. These devices employ fine mesh overlays at the aneurysm neck to decelerate blood inflow, promoting thrombosis and healing while excluding the lesion from circulation. Recent studies demonstrate encouraging safety profiles and short-term success rates, though long-term occlusion data continues to accumulate. These intrasaccular flow disruption technologies represent a transformative approach to managing previously difficult WNBAs, potentially reducing procedural complications while improving clinical outcomes.

# Professional Summary This clinical guidance document addresses post-operative discharge advice for patients following cerebral aneurysm clipping, a surgical procedure in which an aneurysm is secured using a metal clip to prevent rupture. The article provides comprehensive recommendations for managing patients in the immediate post-operative period and during their recovery at home. Key aspects covered include activity restrictions, medication management, symptom monitoring, and follow-up care protocols that patients should observe after undergoing aneurysm clipping surgery. The guidance emphasizes the importance of patient education regarding warning signs of complications, such as increased headache, vision changes, or neurological deterioration, which may indicate post-operative issues requiring immediate medical attention. This resource is significant for neurosurgical teams, discharge planners, and primary care providers involved in supporting aneurysm patients' recovery trajectories, ensuring consistent, evidence-based post-operative management that optimizes patient outcomes and reduces readmission rates following this critical neurosurgical intervention.

Lacunar stroke management follows standard acute ischemic stroke protocols, prioritizing medical stability and thrombolysis eligibility assessment. Intravenous thrombolysis using tissue plasminogen activator (tPA) remains the mainstay treatment when administered within 4.5 hours of symptom onset. Tenecteplase has emerged as the preferred thrombolytic agent based on phase 3 trials demonstrating noninferiority to alteplase with simpler single-bolus administration, as endorsed by the 2026 AHA/ASA guidelines. Alteplase remains an alternative option. For patients with salvageable ischemic penumbra detected on CT/MRI perfusion imaging who present within nine hours of symptom onset, intravenous thrombolysis is recommended. Antiplatelet therapy should be delayed 24 hours post-thrombolysis pending neuroimaging confirmation of no intracranial hemorrhage. The ongoing LAC-3 trial is evaluating cilostazol and isosorbide mononitrate efficacy for preventing adverse outcomes in small vessel lacunar stroke. Mechanical thrombectomy indications have expanded beyond the traditional six-hour window to 16-24 hours, supported by the DAWN and DEFUSE 3 trials, utilizing advanced CT or MRI perfusion imaging for candidate selection.

Cerebral aneurysms, bulges in cerebral arteries, pose severe risks if ruptured, with approximately half of patients experiencing death or severe disability. While endovascular treatment has long offered a minimally invasive approach, traditional coil embolization presents significant challenges, particularly with wide-neck aneurysms where coils risk migrating into the parent artery. The introduction of the Woven EndoBridge (WEB) device has fundamentally transformed acute aneurysm management. Unlike coiling, which requires stent placement and prolonged dual antiplatelet therapy (DAPT), the WEB mesh basket is deployed directly within the aneurysm to disrupt blood flow and induce thrombosis without exposing the parent artery to metal. This eliminates the need for extended DAPT, a critical advantage in ruptured cases where additional interventions like external ventricular drainage or craniotomy may be needed. The simplified procedural steps—requiring only single WEB placement versus the complex coiling sequence—have reduced operative times to less than half compared to traditional methods. The WEB represents a paradigm shift in acute cerebral aneurysm treatment, offering clinically superior outcomes with reduced procedural complexity and medication burden.

Mechanical thrombectomy represents the standard treatment for acute ischemic stroke caused by large vessel occlusions. This systematic review compared the radially adjustable Tigertriever device with conventional self-expanding stent retrievers (SE-SRs), which deploy with fixed radial force. Researchers conducted a comprehensive search across PubMed, Cochrane, Embase, and ClinicalTrials.gov following PRISMA guidelines, analyzing three retrospective cohort studies encompassing 476 patients: 210 treated with Tigertriever and 266 with SE-SRs. The analysis evaluated successful reperfusion rates using the modified Thrombolysis in Cerebral Infarction scale, procedural adverse events including vasospasm and perforation, symptomatic intracranial hemorrhage within 24 hours, functional independence at 90 days, and mortality. Tigertriever demonstrated significantly superior efficacy, achieving successful reperfusion in 82.8% of cases compared to 77.8% with SE-SRs (odds ratio 1.74, p=0.03). The operator-controlled, radially adjustable design of Tigertriever allows tailored expansion and modulation of vessel wall pressure, providing clinicians with enhanced flexibility during thrombectomy procedures. These findings suggest Tigertriever may offer improved outcomes for patients with large vessel occlusions across multiple intracranial locations including the internal carotid artery, middle cerebral artery, and basilar artery.

# Professional Summary This systematic review examines the clinical outcomes and hemodynamic effects of flow diversion treatment for proximal superior cerebellar artery aneurysms, published in Neurosurgical Review in July 2026. Flow diversion represents an endovascular technique that uses specialized stents to redirect blood flow away from aneurysms, promoting thrombosis while preserving parent vessel patency. The research synthesizes existing clinical data to evaluate the safety and efficacy of this approach for this challenging anatomical location, which historically posed significant treatment difficulties due to the vessel's complex branching patterns and eloquent surrounding anatomy. The study includes an exploratory hemodynamic analysis to understand the mechanisms underlying flow diversion success in these cases. By characterizing clinical outcomes including aneurysm occlusion rates, retreatment requirements, and complication profiles, this work provides critical evidence for optimal management strategies. These findings are significant for neurosurgeons and neurointerventionalists treating complex proximal superior cerebellar artery aneurysms, offering evidence-based guidance for patient selection and treatment planning while advancing understanding of flow diversion biomechanics in challenging anatomical scenarios.

In this multicenter retrospective cohort of distal small-vessel flow diversion with the p48 MW HPC, prasugrel-based SAPT was not associated with a significant increase in thromboembolic/ischemic events compared with DAPT; angiographic occlusion and hemorrhage signals were exploratory, with numerically fewer intracranial hemorrhages under SAPT without statistical significance.

Flow diverting stent (FDS) devices have revolutionized the treatment of large and complex brain aneurysms, but there is still room for improvement, particularly on the flow diversion properties and technical challenges associated with stent deployment. In this study we compared flow diversion properties between the new generation Surpass Evolve (Stryker) and the Pipeline Flex (Medtronic) devices by quantitatively evaluating intra-aneurysmal flow modification.

The flow diversion effects of both stents were limited to flow velocity reduction. In a non-thrombosed aneurysm or an aneurysm with delayed thrombosis, the intra-aneurysmal pressure remains essentially unchanged regardless of the level of the intra-aneurysmal flow velocity reduction induced by the stents.

When widely applied, standardization of methods of measuring and reporting outcomes will help to harmonize the assessment of treatment outcomes in clinical studies, help facilitate communication of results among specialists, and help enable research and development to focus on specific aspects of FD techniques and technology.