Angiography‑based quantitative flow ratio for functional assessment of intracranial atherosclerotic disease May 17, 2024, 10:35 a.m.
The μQFR was significantly associated with symptomatic ICAS and outperformed the angiographic stenosis severity. The final nomogram effectively discriminated symptomatic lesions and may provide a useful tool for risk stratification in ICAS patients.
Strategies for surface coatings of implantable cardiac medical devices May 17, 2024, 10:29 a.m.
The design of blood-compatible materials requires understanding the physiological mechanisms that give rise to undesirable blood-material interactions. In particular, the materials used in the design of CMDs are determined by the disease for which the CMDs are intended. For example, we review the utility of polymers in developing CMDs when the necessary materials need to be flexible and durable. On the other hand, when there is a need of materials with high mechanical resistance or more remarkable conductors, metals, and metals alloys are the best option. Also, the combination of these two types of materials is used to develop and enhance the ability to perform high workflow rates in CMDs. Even though metals and polymers have tremendous advantages in developing CMDs, there is a predominant recurring challenge, which is biocompatibility.
Vascular Endothelial Growth Factor (VEGF) and Its Role in the Cardiovascular System May 14, 2024, 11:32 a.m.
Cardiovascular diseases remain the leading cause of death worldwide, with ischemic heart disease (IHD) as the most common. Ischemia-induced angiogenesis is a process in which vascular endothelial growth factor (VEGF) plays a crucial role. To conduct research in the field of VEGF’s association in cardiovascular diseases, it is vital to understand its role in the physiological and pathological processes in the heart. VEGF-based therapies have demonstrated a promising role in preclinical studies. However, their potential in human therapies is currently under discussion. Furthermore, VEGF is considered a potential biomarker for collateral circulation assessment and heart failure (HF) mortality. Additionally, as VEGF is involved in angiogenesis, there is a need to elucidate the impact of VEGF-targeted therapies in terms of cardiovascular side effects.
CereVasc Announces $70 Million Series B Financing to Advance its Novel eShunt® System for the Treatment of Normal Pressure Hydrocephalus May 14, 2024, 8:39 a.m.
Proceeds from the financing will be used to support the clinical and regulatory development of CereVasc's eShunt System, including its upcoming STRIDE pivotal study in patients with Normal Pressure Hydrocephalus. STRIDE is a multi-center, randomized controlled trial that will assess the safety and efficacy of the eShunt System compared to the current standard-of-care ventriculo-peritoneal (VP) shunt and serve as the basis for a future Premarket Approval (PMA) submission to the FDA.
Scientia secures FDA approvals for Plato 17 and Socrates 38 catheters May 12, 2024, 2:12 p.m.
Scientia Vascular chief commercial officer Paul Fischer said: “We’ve seen what microfabrication can do in products like our Aristotle 24 and Colossus wires in changing the standard of care for patient treatment in stroke, so it’s rewarding to see the excitement and buzz surrounding microfabricated technology in catheters with our physician community.
Route 92 Medical Inc. Recalls Catheter due to Distal Tip Separation at the Proximal Marker Band May 12, 2024, 2:04 p.m.
Route 92 Medical Inc. is recalling specific lots of Route 92 Medical products containing the Tenzing 7 Delivery Catheters due to multiple instances of distal tip separation at the proximal marker band. The catheters that deconstructed were not manufactured by Route 92 Medical but by an outside contract supplier. Additional investigations determined that some of these catheters manufactured by this outside supplier did not meet Route 92 Medical’s quality standards particularly in the area of the proximal marker band, so a voluntary recall was initiated.
1380 Institutes Certified to Conduct Clinical Trials in China May 10, 2024, 9:51 a.m.
Since February 2005 when NMPA (then CFDA) published the first batch of medical device clinical sites, a total of 1380 hospitals became certified to conduct clinical research in China as of April 2024. All 1380 sites have different clinical specialties registered with NMPA. We can help you select the right hospital and save time for market introduction.
Plato & Socrates: Disruptive Neurovascular Catheter Receives FDA Approval May 9, 2024, 5:34 p.m.
The reason for the unrivaled flexibility and stability of Plato 17 is the unique micro-machining technology used in Plato 17. Plato 17 has thousands of transition zones to ensure a seamless flexibility gradient: a continuous transition flexibility profile designed to prevent prolapse from selected vessels.Plato 17's unique design: using intricately machined rings and beams on a nickel-titanium tubing (think of it as a 160cm-long nickel-titanium scaffold), a near one-to-one push response is achieved by directly pushing the transition from the proximal to the distal end. This not only prevents kinking, but also helps maintain lumen integrity even in challenging vessels. In sharp contrast, conventional braided and coiled devices tend to accumulate energy, leading to instability and unpredictability
Onyx Gel or Coil versus Hydrogel as Embolic Agents in Endovascular Applications: Review of the Literature and Case Series May 6, 2024, 1:41 p.m.
Although from a commercial point of view coil and Onyx remain the main agents used in clinical practice, it has been observed that in some circumstances they do not guarantee adequate safety and feasibility profiles to maintain human health unaltered. In fact, side effects often occur related to the ease of aggregation, off-target embolisation, collateral circulation, migration and compaction of the spirals, or the presence of solvents such as DMSO (in the case of Onyx), which cause a significant response inflammatory in patients. For this reason, in recent years, scientific research has led to the development of new biomaterials capable of satisfying the growing clinical demands of minimally invasive endovascular embolisation. A variety of embolic materials have been gradually developed, and more research interests have focused on the development of intelligent and/or multifunctional materials. An example is given by embolic agents based on hydrogels, biomaterials of natural or synthetic origin, which are easily customizable with favourable properties and wide versatility.
CERENOVUS launches catheter to treat acute ischemic stroke April 27, 2024, 3:17 p.m.
CERENOVUS, part of Johnson & Johnson MedTech, has launched CEREGLIDE 71 Aspiration Catheter in Europe, an aspiration catheter equipped with TruCourse technology, indicated for the revascularisation of patients suffering from acute ischemic stroke.
Robotic thread is designed to slip through the brain’s blood vessels April 26, 2024, 3:36 a.m.
MIT engineers have developed a magnetically steerable, thread-like robot that can actively glide through narrow, winding pathways, such as the labrynthine vasculature of the brain.
LDL-C Levels and Bleeding Risk in Patients Taking DAPT After Minor Ischemic Stroke or TIA April 24, 2024, 2:54 a.m.
These findings suggest that low LDL-C levels are associated with an increased bleeding risk within 3 months among patients with minor ischemic stroke or high-risk transient ischemic attack who are receiving dual antiplatelet therapy, especially those taking ticagrelor-aspirin.
Neurotechnology Development Must Be Slow and Steady April 24, 2024, 2:51 a.m.
Deployed in the correct manner, future BCIs have the potential to enable their users to control computers with their thoughts after loss of function. This could be life-changing for millions of patients with conditions such as locked-in syndrome, amyotrophic lateral sclerosis (ALS), or tetraplegia. Clinical research and testing of devices for various conditionsopens in a new tab or window is ongoing, and several companiesopens in a new tab or window have made significant stridesopens in a new tab or window to bring these devicesopens in a new tab or window toward commercialization and reaching patients.
Stress induced self-rollable smart-stent-based U-health platform for in-stent restenosis monitoring April 24, 2024, 2:48 a.m.
The preliminary findings confirmed the proposed smart stent's higher level of structural integrity, durability and repeatability. Finally, the practical feasibility of the smart stent is demonstrated by monitoring diastole and systole at various beat rates using a phantom. The results of the phantom study showed a similar pattern to the human model, indicating the potential use of the proposed multifunctional smart stent for real-time applications.
Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility April 24, 2024, 2:32 a.m.
The interaction of biomaterials with blood leads to cellular as well as humoral reactions, which can result in an unwanted inflammation and activation of coagulation and/or fibrinolysis. Thus, the development of biomaterials with an improved hemocompatibility increases the tolerability and minimizes unwanted side effects, such as thrombus formation. Therefore, during the development of new blood-contacting medical devices, not only the mechanical and chemical characteristics should play an important role, but also the hemocompatibility. Furthermore, to prove the safety and reliability of new products, hemocompatibility analyses should include appropriate references and follow the ISO 10993-4 standard.
An In Vitro Blood Flow Loop System for Thrombogenicity Evaluation of Medical Devices and Biomaterials April 24, 2024, 2:31 a.m.
There is currently no standardized test method for in vitro dynamic thrombogenicity assessment of medical devices and biomaterials. This tool will effectively enable users to differentiate device materials with different thrombogenic potentials against standard negative and positive control materials and a marketed comparator device with known thrombogenicity profile.
Comparison of animal and human blood for in vitro dynamic thrombogenicity testing of biomaterials April 24, 2024, 2:29 a.m.
These results demonstrated that multiple animal blood sources (particularly donor ovine and bovine blood) may be suitable alternatives to fresh human blood for dynamic thrombogenicity testing when appropriate control materials and donor-specific anticoagulation levels are used.
Data Extraction from Free-Text Reports on Mechanical Thrombectomy in Acute Ischemic Stroke Using ChatGPT: A Retrospective Analysis April 22, 2024, 11:57 a.m.
To evaluate the use of the large language models (LLMs) GPT-4 and GPT-3.5 to extract data from neuroradiology reports on mechanical thrombectomy in patients with ischemic stroke.
NeuroVita's NOVA® Intracranial Drug-Eluting Stent Direct Molding in M1 Segment Stenosis and 1-Year Follow-Up Results April 18, 2024, 6:48 a.m.
In ICAS surgical treatment, when the anterior-posterior diameter difference of the diseased vessel is found to be small and the vessel segment is relatively straight, we can effectively utilize the NOVA® Intracranial Drug-Eluting Stent with the intermediate catheter in place. The use of the NOVA® Intracranial Drug Eluting Stent can significantly simplify the surgical process, reduce the difficulty of the operation, and thus effectively minimize the complications that may arise during the operation. This strategy not only improves the safety of the operation, but also enhances the patient's recovery
Stroke Trends From 1990 to 2019: Hemorrhagic Stroke Rates Increase in US April 16, 2024, 9:48 a.m.
In the US between 1990 and 2019, age-standardized stroke rates have decreased, however, the rates of absolute burden and hemorrhagic stroke have increased.