The first comparative analysis from the ENGULF (A Safety and Feasibility Single-Arm Study of a Novel Catheter Thrombectomy Device For the Treatment of Pulmonary Embolism) trial shows that using blood return during continuous aspiration thrombectomy dramatically reduces blood loss by 97%, while maintaining hemodynamic efficacy and improving procedural efficiency. Researchers presented the late-breaking data today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2026 Scientific Sessions & Canadian Association of Interventional Cardiology/Association Canadienne de cardiologie d'intervention (CAIC-ACCI) Summit in Montreal. 

In a groundbreaking advancement for stroke therapy, a recent randomized clinical trial published in Nature Communications brings to light the synergistic effects of albumin administration combined with endovascular therapy for treating acute ischemic stroke patients. Acute ischemic stroke, a leading cause of disability and mortality worldwide, results from an abrupt obstruction of cerebral blood flow, often eliciting irreversible brain damage if not rapidly managed. While mechanical thrombectomy through endovascular techniques has revolutionized treatment by physically removing the occlusion, therapeutic adjuncts to enhance outcomes remain a critical unmet need. This study, led by Liu, Dong, Zhang, and colleagues, pioneers the exploration of albumin—a naturally abundant plasma protein—as a potential amplifier of neuroprotection and vascular restoration when paired with endovascular intervention.

“Engineered for the rapid removal of pulmonary and venous thrombus, the latest Flash 3.0 algorithm is designed for enhanced clot detection capabilities with increased sensitivity to thrombus and blood,” Penumbra reported in a press release. The latest iteration includes enlarged tubing coupled with an automated backflush feature tailored for large thrombus burdens and to reduce friction from aspirated thrombus.The STORM-PE randomised controlled trial, recently published in Circulation, found that the use of Penumbra’s CAVT technology with anticoagulation achieved superior reduction in right heart strain compared to anticoagulation therapy alone in patients with acute intermediate-high risk pulmonary embolism (PE). This marks the first level-1 evidence demonstrating superior results for mechanical thrombectomy over traditional anticoagulation for the treatment of pulmonary embolism (PE).

California-based medtech E2 (Endovascular Engineering) has raised $80 million in a series C funding round as it looks to commercialize its pulmonary embolism treatment. The Hēlo Thrombectomy Platform received FDA clearance late last year for use in peripheral veins to treat pulmonary embolism without the need for surgical intervention. The innovation behind the tech is its dual-action mechanism, which combines aspiration with mechanical clot disruption and is delivered through a small-profile catheter. 

Wallaby, with its main offices in Laguna Hills, California and Shanghai, China achieves a significant portion of sales of its world-class and premier-quality products in the U.S. and other major developed markets. phenox, headquartered in Bochum, Germany, provides a broad portfolio of neurovascular devices to treat ischemic and hemorrhagic strokes that are sold in over 45 countries worldwide. The two companies have been strategic partners since 2019. phenox has been the exclusive distributor for Wallaby’s Avenir® Coil System in the U.S. and European markets as well as for Wallaby’s EsperanceTM Aspiration Catheters in the U.S. market.

Big ideas are common in medicine. Turning them into real products is not. David Ferrera has spent nearly 30 years doing exactly that. He is an engineer, entrepreneur, and inventor based in Lake Forest, California. Over his career, he has helped build and sell multiple medical device companies. He holds more than 80 U.S. and international patents. He is also the author of Innovation in Translation: How Big Ideas Really Happen. But his focus is simple. “Innovation is important,” Ferrera says. “Translation is everything.”

The molecule EMA601 precisely targets glycoprotein VI (GPVI), a platelet-specific receptor crucially implicated in thrombus formation and thrombo-inflammatory disease pathways. Unlike general antithrombotic agents that often interfere with primary hemostasis, EMA601 selectively inhibits pathological platelet activation without compromising the essential clotting functions necessary for safe hemostasis. This specificity stems from GPVI’s unique expression profile and its pivotal role in triggering platelet responses upon vascular injury, by binding exposed collagen and initiating intracellular signaling cascades.

As detailed in a company press release, intracranial atherosclerotic disease (ICAD) is a leading cause of ischaemic stroke worldwide and remains “one of the most challenging areas in cerebrovascular therapy”. Patients with medically refractory ICAD face limited treatment options, and effective interventional approaches to restore cerebral blood flow represent a “significant unmet clinical need”. To this end, Apollo Dream—MicroPort NeuroScientific’s investigational, balloon-expandable, rapid-exchange drug-eluting stent system—has been designed to provide vascular scaffolding and restore cerebral blood flow. The company says it is not aware of any other devices with this specific combination of features that have received a US FDA Breakthrough Device designation covering this indication.

The diameter of NOVA NEO stent covers 2.25mm to 4.00mm, and the length is 7mm to 20mm, which adapts to the needs of different blood vessel diameters and lesion lengths. The expansion of the balloon is completed synchronously with the release of the stent, which simplifies the surgical process and reduces the difficulty of operation. When passing through severe tortuous blood vessels, its flexibility, The passability performance is good, and the support for blood vessels after stent expansion is good, which can prevent the risk of stenosis of the stent after plaque retraction.

Stent thrombosis (ST) is a catastrophic event and efforts to reduce its incidence by altering blood-stent interactions are longstanding. A new electret coating technology that produces long-lasting negative charge on stent surface could make them intrinsically resistant to thrombosis. We assessed the thrombogenicity of stents using an annular perfusion model with confocal microscopy, and determined the efficacy of electret coating technology to confer thrombo-resistant properties to standard stents. Using an annular perfusion chamber, Bare Metal Stent (BMS), standard uncoated DES (DES), and Electret-coated DES (e-DES) were exposed to human blood under arterial flow conditions. Deposits of fibrinogen and platelets on the stent surface were analyzed using immunofluorescence staining and confocal microscopy. Surface coverage by fibrinogen and platelets and the deposit/aggregate size were quantified using computerized morphometric analysis.

Early FD implantation in carefully selected ruptured aneurysms, including small saccular and morphologically complex lesions can achieve high functional recovery and complete angiographic occlusion, even in a resource-limited environment. Ideal case selection and standardized DAPT and hemodynamic protocols are critical. These findings support broader use in challenging aneurysms, but larger prospective studies are warranted to validate outcomes and refine management strategies.

XCath has secured US$30 million in Series C funding, bringing the total raised since the company’s inception to US$92 million, with these latest funds set to support XCath’s ongoing efforts to bring “the world’s first commercially practical endovascular robot” to the market—and to perform a clinical telerobotic mechanical thrombectomy procedure.

Early FD implantation in carefully selected ruptured aneurysms, including small saccular and morphologically complex lesions can achieve high functional recovery and complete angiographic occlusion, even in a resource-limited environment. Ideal case selection and standardized DAPT and hemodynamic protocols are critical. These findings support broader use in challenging aneurysms, but larger prospective studies are warranted to validate outcomes and refine management strategies.

The overall blood flow distribution of stents with different cross-sections is similar, but there are differences in the local average flow velocity of the tumor cavity: the circular one is the highest, and the quadrilateral one is the lowest. (3) The wall pressure gradient change of the polygonal stent is gentler than that of the circular one. Among them, the wall pressure of the hexagonal and decagonal stents is the maximum and the average pressure in the cavity is the lowest. (4) The area of the low WSS region on the aneurysm wall is the largest in quadrilaterals and the smallest in circles. On the maternal artery segment, the hexagon is the largest and the quadrilateral is the smallest. Comprehensive comparison shows that quadrilateral and decagonal cross-section stents exhibit better comprehensive performance.

Features of the NOVA Intracranial Drug-Eluting Stent:1. Precise Positioning: The stent can accurately reach its intended location during deployment, reducing the risk of stent migration;2. Excellent Conformability: Typically navigates tortuous vascular segments with ease. Even in severely tortuous vessels, techniques such as adjusting guidewire tension or employing intermediate catheters for additional support facilitate successful stent placement, thereby reducing procedure failure rates due to vascular tortuosity;3. Excellent Adherence: Post-deployment, the stent adheres closely to the vessel wall, effectively reducing complications such as intrastent thrombosis and facilitating the restoration of normal vascular function post-surgery. This case utilised a 2.25-10mm NOVA NEO™ intracranial drug-eluting stent, requiring high-positioning of the guidewire and a micro-guidewire with strong support capability to ensure successful placement and prevent stent displacement during deployment.

An investigational stent retriever device was highly effective in restoring blood flow in distal vessel ischemic stroke.Data on key secondary efficacy and safety endpoints will be presented at a later date.

At first glance, the platelet is a simple cell. However, its small size hides an extremely well conserved structure that is vital for its function in both hemostasis and vascular integrity and development. A combination of electron microscopy, light microscopy, biochemical, and cell biology studies has, over the years, revealed this structure to us and allowed the important functions of the various organelles and subcellular components to be understood. This chapter reviews the structure of the resting platelet and discusses the dramatic and dynamic changes, especially in the cytoskeleton, that occur upon activation to allow platelets to carry out their primary function in hemostasis.

Large-artery ischemic (clot-caused) strokes account for about 1 in 4 ischemic strokes, according to study author ángel Chamorro, M.D., Ph.D., professor of neurology at the University of Barcelona and head of the Comprehensive Stroke Center Hospital Clinic in Barcelona. These types of strokes can cause death and long-term disability because they block large arteries that supply blood to significant areas of the brain.

Initiée par le Ministère de la Recherche de l’Enseignement Supérieur et de l’Innovation, cette démarche est coordonnée par le Gircor, et fait écho à des initiatives similaires dans d’autres pays européens. En tant que signataire de cette Charte de transparence, la Société des Neurosciences s’engage à mieux informer le grand public sur l’utilisation d’animaux dans la recherche scientifique française en neurosciences.

Naox Technologies has become the first medtech company to receive FDA clearance for its in-ear EEG device that can negate the need for complex and limited scalp electrodes that have been used for brain monitoring for decades.Naox Link is an electroencephalography (EEG) platform that patients use via a small sensor worn in the ear, allowing brain activity to be monitored while they move around. According to a Jan. 6 release, the approach “enables long-duration, real-world brain monitoring beyond traditional hospital environments.”