Xeltis expands leadership team with appointment of Luc Verhees as Vice President of Clinical Business Development www.prnewswire.com Nov. 11, 2024, 10:25 a.m.
Luc's appointment further strengthens the Company's leadership team, as Xeltis expands its clinical presence following the approval of an Investigational Device Exemption (IDE) from the US Food and Drug Administration (FDA) to initiate a US pivotal study for aXess, its restorative vascular access conduit. Luc is familiar to Xeltis having previously served as Senior Vice President of Global Clinical Affairs from 2018 to 2020, and this previous experience of working with Xeltis' transformative Endogenous Tissue Restoration (ETR) technology in a clinical capacity will be invaluable as the Company continues its development.
Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases www.sciencedirect.com Oct. 17, 2024, 10:20 a.m.
AST modulates inflammatory signaling pathways such as NF-kB and downregulates the expression of inflammatory cytokines. Although there are only a few clinical reports related to the protective effect of AST against inflammatory diseases, AST should be further characterized for its properties as a potential therapeutic strategy in combating inflammatory diseases.
Le groupe sanguin influence le risque d'AVC précoce, suggère une étude trustmyscience.com Oct. 14, 2024, 5:55 p.m.
Les accidents vasculaires cérébraux (AVC), principalement de nature ischémique, trouvent leurs racines dans divers facteurs, parmi lesquels l’athérosclérose occupe une place prépondérante. Cette pathologie se manifeste par la formation de plaques au sein des parois artérielles. Bien que les individus âgés soient généralement plus vulnérables aux AVC, une tendance inquiétante émerge : l’augmentation des cas d’AVC précoce. Une étude récente menée par des chercheurs américains révèle un lien insoupçonné entre ce phénomène et le groupe sanguin. Les conclusions de cette étude indiquent notamment que les individus du groupe sanguin A présentent un risque supérieur de subir un AVC précoce, en comparaison avec ceux des groupes sanguins B et O.
Smartphone application-based intervention to lower blood pressure: a systematic review and meta-analysis www.nature.com Oct. 14, 2024, 5:53 p.m.
Nowadays, the mHealth market is flooded with smartphone applications (apps) lacking validation for blood pressure (BP)-lowering effects and BP measurement accuracy. This systematic review for Guidelines for BP control using digital technologies of the Japanese Society of Hypertension aimed to assess the validation studies of apps.
Advancements in Polymer Biomaterials as Scaffolds for Corneal Endothelium Tissue Engineering www.mdpi.com Oct. 14, 2024, 3:44 p.m.
Corneal endothelial dysfunction is a leading cause of vision loss globally, frequently requiring corneal transplantation. However, the limited availability of donor tissues, particularly in developing countries, has spurred on the exploration of tissue engineering strategies, with a focus on polymer biomaterials as scaffolds for corneal endotlhelium regeneration. This review provides a comprehensive overview of the advancements in polymer biomaterials, focusing on their role in supporting the growth, differentiation, and functional maintenance of human corneal endothelial cells (CECs).
Cancer, accident, AVC… Quelle est la première cause de mortalité en France ? www.20minutes.fr Oct. 9, 2024, 12:42 p.m.
Santé publique France, la Drees et l’Inserm ont publié une étude sur les causes principales de mortalité en France en 2022. Selon cette dernière, un quart des décès sont liés à des tumeurs, 20 % surviennent à la suite d’une maladie cardio-vasculaire
Therapeutic effects of different acupuncture methods on chronic nonspecific low back pain josr-online.biomedcentral.com Oct. 7, 2024, 9:14 a.m.
For CNLBP patients, warm needle acupuncture, electrical warm needling and meridian-sinew theory-based treatment are mainly recommended. If patients have significant pain, electroacupuncture is strongly suggested. On the contrary, for patients with decreased joint mobility, meridian-sinew theory-based treatment is advocated.
Clinical outcomes of drug-coated balloons dilatation for benign esophageal stricture bmcgastroenterol.biomedcentral.com Oct. 7, 2024, 8:21 a.m.
DCBs dilatation may be a safe, effective and feasible treatment for benign esophageal strictures, and can be utilized as an alternative option after standard dilatation has failed. Prospective studies with large samples are needed to further validate its clinical efficacy.
À 15 ans, Heman Bekele a inventé un savon qui traite le cancer de la peau creapills.com Sept. 2, 2024, 12:52 p.m.
Pour cela, ce petit génie en herbe a élaboré une formule chimique composée d’acide salicylique, d’acide glycolique et de trétinoïne, qui favorise l’activation de cellules indispensables au bon fonctionnement du système immunitaire et à la détection d’agents pathogènes potentiels. Il a ensuite ajouté ce mélange à une nanoparticule à base de lipides afin qu’elle ne se dissolve pas avec la mousse du savon et puisse pénétrer la peau.
Electroacupuncture Reduced Fibromyalgia-Pain-like Behavior through Inactivating Transient Receptor Potential V1 and Interleukin-17 www.mdpi.com Aug. 31, 2024, 2:17 p.m.
We found that FM-pain-like behavior induced in the ICS mice model elevated the plasma IL-17A and the brain IL-17RA. The results indicated that IL-17A plays a critical role in peripheral and central sensitization as well as neuroinflammation in the ICS FM mice model. Additionally, both EA and Trpv1−/− attenuated the plasma IL-17A and the brain IL-17RA. We also found that Trpv1−/− abolished the IL-17A, IL-17RA, and their downstream pathways, such as PI3K/Akt, MAPKs, and NF-κB. Therefore, IL-17A–IL-17RA might not induce neuroinflammation without TRPV1. Finally, our results indicated that EA relieved the ICS-induced FM mechanical and thermal pain-like behaviors maybe through the TRPV1–IL-17-related pathways in mice. It suggests that EA could lower the use of drugs and other additional pain treatment and is a potential therapeutic strategy in FM.
Quand une consommation excessive et chronique de Coca vous envoie à l’hôpital www.lemonde.fr Aug. 26, 2024, 9:01 a.m.
Entre 2001 et 2019, plusieurs cas d’hypokaliémie liés à une consommation excessive de cola ont été rapportés dans la littérature par des médecins britanniques, sud-coréens, américains, grecs, turcs et belges, chez des patients présentant des symptômes musculaires et neurologiques plus ou moins sévères.
A Possible Reversible Cause of Cognitive Impairment: Undiagnosed Cirrhosis and Potential Hepatic Encephalopathy in Patients with Dementia www.amjmed.com Aug. 24, 2024, 12:28 p.m.
Dementia and hepatic encephalopathy (HE) have symptom overlap and are challenging to differentiate. The presence of undiagnosed cirrhosis may lead to missed opportunities to treat HE, which was found in a veterans database. This needs validation in a non-veteran cohort.
Family Size, Dog Ownership May Lower Risk of Crohn's Disease www.medscape.com Aug. 24, 2024, 12:28 p.m.
People who live with at least two other people in their first year of life and have a dog during childhood may be at reduced risk of developing Crohn's disease (CD), according to investigators.
From Assessing Risk Factors to Understanding, Preventing, and Treating Cardiovascular Diseases: an Urgent Journey www.discoverymedicine.com Aug. 19, 2024, 8:59 a.m.
The development of CVD in the context of acidemia and high blood concentration of FA, already presented in previous works, has been extended here to include recent developments. It has shown how unique aspects of CVD can be explained in this framework, namely the role of apoB100. The distinct nature of heart attack from cardiac death caused by hypoxia due to carbon monoxide poisoning was highlighted. The role of KATP channels and their relationship with blood pH has been discussed as a possible origin of arterial spasm and cardiomyocyte death. Finally, it was shown how the main cardiovascular risks could be understood in light of the proposed model.
The Skinny on What We Know About the Microbiome and Obesity www.medscape.com July 31, 2024, 12:03 p.m.
When we think about what microbes do, the first thing that comes to mind is that they help with digestion and energy metabolism. More recently, we've seen a correlation between the loss of gut microbiome diversity and the obesity pandemic across this country and across the world.
How Aspirin May Lower Risk for Colorectal Cancer www.medscape.com July 28, 2024, 4:04 p.m.
A growing body of evidence has shown that people who regularly take aspirin have a lower risk for colorectal cancer (CRC) and are less likely to die if they do develop the disease.
Mounjaro Beats Ozempic, So Why Isn't It More Popular? www.medscape.com July 20, 2024, 12:24 p.m.
I can explain that I prescribed a glucagon-like peptide 1 (GLP-1) receptor agonist because the patient had diabetes and was overweight, and multiple studies show that this class of drug leads to weight loss and reduced mortality risk. But then I get the follow-up: Sure, but why THAT GLP-1 drug? Why did you pick semaglutide (Ozempic) over tirzepatide (Mounjaro)? Here's where I run out of good answers. Sometimes I choose a drug because that's what the patient's insurance has on their formulary. Sometimes it's because it's cheaper in general. Sometimes, it's just force of habit. I know the correct dose, I have experience with the side effects — it's comfortable.
Tattoo Ink Found to Be Contaminated With Bacteria www.medscape.com July 20, 2024, 12:16 p.m.
When US researchers tested 75 unopened and sealed tattoo and permanent makeup inks from 14 different manufacturers, they discovered that about 35% of the products were contaminated with bacteria. They detected both aerobic bacteria, which require oxygen, and anaerobic bacteria, which thrive in low-oxygen environments like the dermal layer of the skin.
How Music Synchronizes Heart Rates and Collective Emotions neurosciencenews.com July 19, 2024, 7:52 p.m.
Listening to music synchronizes heart rates within individuals more reliably than between different people. This synchronization depends on physiological responses rather than mood or music preferences. The findings help explain the collective emotional experiences of audiences and suggest ways to enhance theater performances. The research offers valuable clues for improving the performing arts.