The evolutionary potential of the human immune system in space deals with many (yet unknown) obstacles. Such challenges include different pathogenic potential in microorganisms, altered immune response, low genetic variability, and large immune variability due to small population sizes to name a few. Reflecting on the evolutionary journey of immunity to a future in outer space reveals a crucial insight: the intricate and multifaceted actions and interactions within innate and adaptive immunity stem from a rigorous and enduring process of selection and deselection as described.

Prostatic stents remain an efficient choice for addressing obstructive symptoms from BPH, offering the advantage of being performed under local anaesthesia, relieving symptoms with good functional outcomes and a low incidence of major complications. Prospective studies are needed to corroborate these results.

Ce dimanche 28 juillet, une nouvelle étude publiée dans la revue scientifique JAMA dévoile les très bons résultats d'un test sanguin pour diagnostiquer la maladie d'Alzheimer, 20 ans avant l'apparition des symptômes. Autrement dit, une simple prise de sang permettrait de prendre en charge plus tôt un patient atteint d'Alzheimer[1] et d'améliorer son quotidien. Ce test simple, non invasif et peu coûteux serait beaucoup plus efficace à un stade précoce qu'une consultation par un médecin ou même un neurologue. Explications.

Luc's appointment further strengthens the Company's leadership team, as Xeltis expands its clinical presence following the approval of an Investigational Device Exemption (IDE) from the US Food and Drug Administration (FDA) to initiate a US pivotal study for aXess, its restorative vascular access conduit. Luc is familiar to Xeltis having previously served as Senior Vice President of Global Clinical Affairs from 2018 to 2020, and this previous experience of working with Xeltis' transformative Endogenous Tissue Restoration (ETR) technology in a clinical capacity will be invaluable as the Company continues its development.

AST modulates inflammatory signaling pathways such as NF-kB and downregulates the expression of inflammatory cytokines. Although there are only a few clinical reports related to the protective effect of AST against inflammatory diseases, AST should be further characterized for its properties as a potential therapeutic strategy in combating inflammatory diseases.

Les accidents vasculaires cérébraux (AVC), principalement de nature ischémique, trouvent leurs racines dans divers facteurs, parmi lesquels l’athérosclérose occupe une place prépondérante. Cette pathologie se manifeste par la formation de plaques au sein des parois artérielles. Bien que les individus âgés soient généralement plus vulnérables aux AVC, une tendance inquiétante émerge : l’augmentation des cas d’AVC précoce. Une étude récente menée par des chercheurs américains révèle un lien insoupçonné entre ce phénomène et le groupe sanguin. Les conclusions de cette étude indiquent notamment que les individus du groupe sanguin A présentent un risque supérieur de subir un AVC précoce, en comparaison avec ceux des groupes sanguins B et O.

Nowadays, the mHealth market is flooded with smartphone applications (apps) lacking validation for blood pressure (BP)-lowering effects and BP measurement accuracy. This systematic review for Guidelines for BP control using digital technologies of the Japanese Society of Hypertension aimed to assess the validation studies of apps.

Corneal endothelial dysfunction is a leading cause of vision loss globally, frequently requiring corneal transplantation. However, the limited availability of donor tissues, particularly in developing countries, has spurred on the exploration of tissue engineering strategies, with a focus on polymer biomaterials as scaffolds for corneal endotlhelium regeneration. This review provides a comprehensive overview of the advancements in polymer biomaterials, focusing on their role in supporting the growth, differentiation, and functional maintenance of human corneal endothelial cells (CECs).

Santé publique France, la Drees et l’Inserm ont publié une étude sur les causes principales de mortalité en France en 2022. Selon cette dernière, un quart des décès sont liés à des tumeurs, 20 % surviennent à la suite d’une maladie cardio-vasculaire

For CNLBP patients, warm needle acupuncture, electrical warm needling and meridian-sinew theory-based treatment are mainly recommended. If patients have significant pain, electroacupuncture is strongly suggested. On the contrary, for patients with decreased joint mobility, meridian-sinew theory-based treatment is advocated.

DCBs dilatation may be a safe, effective and feasible treatment for benign esophageal strictures, and can be utilized as an alternative option after standard dilatation has failed. Prospective studies with large samples are needed to further validate its clinical efficacy.

Pour cela, ce petit génie en herbe a élaboré une formule chimique composée d’acide salicylique, d’acide glycolique et de trétinoïne, qui favorise l’activation de cellules indispensables au bon fonctionnement du système immunitaire et à la détection d’agents pathogènes potentiels. Il a ensuite ajouté ce mélange à une nanoparticule à base de lipides afin qu’elle ne se dissolve pas avec la mousse du savon et puisse pénétrer la peau.

We found that FM-pain-like behavior induced in the ICS mice model elevated the plasma IL-17A and the brain IL-17RA. The results indicated that IL-17A plays a critical role in peripheral and central sensitization as well as neuroinflammation in the ICS FM mice model. Additionally, both EA and Trpv1−/− attenuated the plasma IL-17A and the brain IL-17RA. We also found that Trpv1−/− abolished the IL-17A, IL-17RA, and their downstream pathways, such as PI3K/Akt, MAPKs, and NF-κB. Therefore, IL-17A–IL-17RA might not induce neuroinflammation without TRPV1. Finally, our results indicated that EA relieved the ICS-induced FM mechanical and thermal pain-like behaviors maybe through the TRPV1–IL-17-related pathways in mice. It suggests that EA could lower the use of drugs and other additional pain treatment and is a potential therapeutic strategy in FM.

Entre 2001 et 2019, plusieurs cas d’hypokaliémie liés à une consommation excessive de cola ont été rapportés dans la littérature par des médecins britanniques, sud-coréens, américains, grecs, turcs et belges, chez des patients présentant des symptômes musculaires et neurologiques plus ou moins sévères.

Dementia and hepatic encephalopathy (HE) have symptom overlap and are challenging to differentiate. The presence of undiagnosed cirrhosis may lead to missed opportunities to treat HE, which was found in a veterans database. This needs validation in a non-veteran cohort.

People who live with at least two other people in their first year of life and have a dog during childhood may be at reduced risk of developing Crohn's disease (CD), according to investigators.

The development of CVD in the context of acidemia and high blood concentration of FA, already presented in previous works, has been extended here to include recent developments. It has shown how unique aspects of CVD can be explained in this framework, namely the role of apoB100. The distinct nature of heart attack from cardiac death caused by hypoxia due to carbon monoxide poisoning was highlighted. The role of KATP channels and their relationship with blood pH has been discussed as a possible origin of arterial spasm and cardiomyocyte death. Finally, it was shown how the main cardiovascular risks could be understood in light of the proposed model.

When we think about what microbes do, the first thing that comes to mind is that they help with digestion and energy metabolism. More recently, we've seen a correlation between the loss of gut microbiome diversity and the obesity pandemic across this country and across the world.

Cold deaths vastly outnumber heat-related ones, but mostly due to “moderate” rather than extremely cold conditions.

A growing body of evidence has shown that people who regularly take aspirin have a lower risk for colorectal cancer (CRC) and are less likely to die if they do develop the disease.