Pour cela, ce petit génie en herbe a élaboré une formule chimique composée d’acide salicylique, d’acide glycolique et de trétinoïne, qui favorise l’activation de cellules indispensables au bon fonctionnement du système immunitaire et à la détection d’agents pathogènes potentiels. Il a ensuite ajouté ce mélange à une nanoparticule à base de lipides afin qu’elle ne se dissolve pas avec la mousse du savon et puisse pénétrer la peau.

We found that FM-pain-like behavior induced in the ICS mice model elevated the plasma IL-17A and the brain IL-17RA. The results indicated that IL-17A plays a critical role in peripheral and central sensitization as well as neuroinflammation in the ICS FM mice model. Additionally, both EA and Trpv1−/− attenuated the plasma IL-17A and the brain IL-17RA. We also found that Trpv1−/− abolished the IL-17A, IL-17RA, and their downstream pathways, such as PI3K/Akt, MAPKs, and NF-κB. Therefore, IL-17A–IL-17RA might not induce neuroinflammation without TRPV1. Finally, our results indicated that EA relieved the ICS-induced FM mechanical and thermal pain-like behaviors maybe through the TRPV1–IL-17-related pathways in mice. It suggests that EA could lower the use of drugs and other additional pain treatment and is a potential therapeutic strategy in FM.

Entre 2001 et 2019, plusieurs cas d’hypokaliémie liés à une consommation excessive de cola ont été rapportés dans la littérature par des médecins britanniques, sud-coréens, américains, grecs, turcs et belges, chez des patients présentant des symptômes musculaires et neurologiques plus ou moins sévères.

Dementia and hepatic encephalopathy (HE) have symptom overlap and are challenging to differentiate. The presence of undiagnosed cirrhosis may lead to missed opportunities to treat HE, which was found in a veterans database. This needs validation in a non-veteran cohort.

People who live with at least two other people in their first year of life and have a dog during childhood may be at reduced risk of developing Crohn's disease (CD), according to investigators.

The development of CVD in the context of acidemia and high blood concentration of FA, already presented in previous works, has been extended here to include recent developments. It has shown how unique aspects of CVD can be explained in this framework, namely the role of apoB100. The distinct nature of heart attack from cardiac death caused by hypoxia due to carbon monoxide poisoning was highlighted. The role of KATP channels and their relationship with blood pH has been discussed as a possible origin of arterial spasm and cardiomyocyte death. Finally, it was shown how the main cardiovascular risks could be understood in light of the proposed model.

When we think about what microbes do, the first thing that comes to mind is that they help with digestion and energy metabolism. More recently, we've seen a correlation between the loss of gut microbiome diversity and the obesity pandemic across this country and across the world.

Cold deaths vastly outnumber heat-related ones, but mostly due to “moderate” rather than extremely cold conditions.

A growing body of evidence has shown that people who regularly take aspirin have a lower risk for colorectal cancer (CRC) and are less likely to die if they do develop the disease.

I can explain that I prescribed a glucagon-like peptide 1 (GLP-1) receptor agonist because the patient had diabetes and was overweight, and multiple studies show that this class of drug leads to weight loss and reduced mortality risk. But then I get the follow-up: Sure, but why THAT GLP-1 drug? Why did you pick semaglutide (Ozempic) over tirzepatide (Mounjaro)? Here's where I run out of good answers. Sometimes I choose a drug because that's what the patient's insurance has on their formulary. Sometimes it's because it's cheaper in general. Sometimes, it's just force of habit. I know the correct dose, I have experience with the side effects — it's comfortable.

When US researchers tested 75 unopened and sealed tattoo and permanent makeup inks from 14 different manufacturers, they discovered that about 35% of the products were contaminated with bacteria. They detected both aerobic bacteria, which require oxygen, and anaerobic bacteria, which thrive in low-oxygen environments like the dermal layer of the skin.

Listening to music synchronizes heart rates within individuals more reliably than between different people. This synchronization depends on physiological responses rather than mood or music preferences. The findings help explain the collective emotional experiences of audiences and suggest ways to enhance theater performances. The research offers valuable clues for improving the performing arts.

A new study finds that higher inflammation in young adulthood is associated with reduced cognitive function in midlife. Researchers discovered that inflammation due to factors like obesity and smoking can impact memory and processing speed. This link, previously noted in older adults, now extends to early adulthood, suggesting long-term brain health effects. Reducing inflammation through lifestyle changes may help prevent cognitive decline.

A new study reveals that psilocybin, the active compound in magic mushrooms, temporarily disrupts brain networks involved in introspective thinking, like daydreaming and memory. These changes persist for weeks, potentially making the brain more flexible and improving mental health. The findings could pave the way for psilocybin-based therapies for depression and PTSD. The research underscores the importance of using these drugs under medical supervision.

Researchers discovered that inhibiting the protein IL-11 extends the lifespan of mice by up to 25%. The treatment also reduces cancer and diseases related to aging. This breakthrough offers potential for future anti-aging therapies in humans. Further clinical trials are necessary to confirm its safety and effectiveness.

Le microbiote intestinal, c'est-à-dire l'ensemble de micro-organismes qui vivent dans nos intestins, a une influence sur l'immunité, la santé mentale, et même le vieillissement. Et il pourrait même jouer un rôle sur la santé de nos enfants !

Chimeric antigen receptor T-cell (CAR-T) therapies have revolutionized the treatment of blood cancer, but scalability remains a major challenge. Experts explain how technologies such as chip-based miniaturized models and automation could be part of the solution.

This procedure was unusual since CAR-T cells had previously only been used for leukemia or lymphoma and during studies on adults with certain advanced autoimmune diseases. These cells had previously never been used for treating children with autoimmune diseases.

"There are still biological barriers to overcome. For example, three out of 10 patients receiving CAR-T therapy for relapsed/refractory large B-cell lymphoma fail because of antigen loss. Dual CAR-T therapies could overcome this resistance mechanism and increase efficacy. We have different strategies, such as tandem CAR-T cells, bicistronic CAR-T cells, cotransduction, and coadministration. Furthermore, there are ongoing studies like Zamto-cel, Prizlo.cel, AUTO3, KITE-363, and KITE-753. Some dual CAR constructs have shown positive results, but more work is needed."

The phase 1 trial is assessing the ROR1-targeted CAR-T cell therapy LYL797 in solid tumor patients. Lyell designed the candidate to overcome T-cell exhaustion, a phenomenon that limited the impact of early ROR1 CAR-T cell therapies on solid tumors. The biotech put the prospect to the test in a dose-escalation study.