The investigation underscores the significance of corrosion resistance and biocompatibility in diverse anatomical cavities. The quintessential biodegradable Mg stent ought to possess stellar mechanical properties, biodegradability, and commendable biocompatibility while taking into account site-specific requisites. The utilization of degradable stents obviates the necessity for secondary interventions and proffers unparalleled advantages in disparate luminal environments. Mg alloys have garnered attention as exceedingly promising materials for multifaceted human implants, owing to their mechanical attributes and degradation kinetics. Nevertheless, challenges such as mechanical support duration, degradation kinetics, biological functionality, and compatibility with minimally invasive therapeutic modalities necessitate redressal for prospective device translation.

The disadvantages of Mg-based stents include their rapid degradation and insufficient endothelialization after implantation. Bioinspired strategies for Mg-based stents can increase not just the corrosion resistance but also their biocompatibility. For instance, bioinspired strategies would exhibit slow degradation by constructing a bioinspired physical barrier to prevent exposure of Mg-based stents to the ambient atmosphere and achieve fast endothelialization after implantation to tackle restenosis problems.

These findings suggest that low LDL-C levels are associated with an increased bleeding risk within 3 months among patients with minor ischemic stroke or high-risk transient ischemic attack who are receiving dual antiplatelet therapy, especially those taking ticagrelor-aspirin.

The preliminary findings confirmed the proposed smart stent's higher level of structural integrity, durability and repeatability. Finally, the practical feasibility of the smart stent is demonstrated by monitoring diastole and systole at various beat rates using a phantom. The results of the phantom study showed a similar pattern to the human model, indicating the potential use of the proposed multifunctional smart stent for real-time applications.

The stent may be used as an antenna coil and may replace supplemental circular or planar coils for receiving power. The stent shape and dimensions may be modified to allow them to receive energy and also provide longer life, thereby having a longer-term treatment. This study is expected to introduce a key database of associated works for researchers in the field. Lastly, the problems and challenges involved in improving the devices and long-term treatments were discussed in detail.

In this paper, we present a stent antenna for intravascular monitoring and implantable wireless applications that employ the entire stent as an antenna. The main contribution of this work was the manipulation of the current distributions of the stent for good radiation performance with a short stent length by exploiting a single connector between each unit of the stent. Unlike a general stent, wherein each unit is connected with multiple connectors, our proposed stent can achieve good EM radiation, maintain good mechanical strength, and remain within fracture limits during balloon expansions. A prototype was designed, fabricated, and experimentally examined with an EM anechoic chamber. The fabricated stent antenna demonstrated an omnidirectional radiation pattern, a gain of 1.38 dBi, and a radiation efficiency of 74.5% at the resonant frequency of 2.07 GHz. The results of this research should contribute to the development of implantable wireless communications and intravascular monitoring of cardiovascular diseases.

The interaction of biomaterials with blood leads to cellular as well as humoral reactions, which can result in an unwanted inflammation and activation of coagulation and/or fibrinolysis. Thus, the development of biomaterials with an improved hemocompatibility increases the tolerability and minimizes unwanted side effects, such as thrombus formation. Therefore, during the development of new blood-contacting medical devices, not only the mechanical and chemical characteristics should play an important role, but also the hemocompatibility. Furthermore, to prove the safety and reliability of new products, hemocompatibility analyses should include appropriate references and follow the ISO 10993-4 standard.

There is currently no standardized test method for in vitro dynamic thrombogenicity assessment of medical devices and biomaterials. This tool will effectively enable users to differentiate device materials with different thrombogenic potentials against standard negative and positive control materials and a marketed comparator device with known thrombogenicity profile.

These results demonstrated that multiple animal blood sources (particularly donor ovine and bovine blood) may be suitable alternatives to fresh human blood for dynamic thrombogenicity testing when appropriate control materials and donor-specific anticoagulation levels are used.

Many people overlook common lifestyle factors that impact their heart health. The survey, conducted by Ipsos, reveals around three in 10 adults are unaware that alcohol (32 percent), smoking (27 percent), and lack of sleep (27 percent) are linked to heart disease.

The interaction of biomaterials with blood leads to cellular as well as humoral reactions, which can result in an unwanted inflammation and activation of coagulation and/or fibrinolysis. Thus, the development of biomaterials with an improved hemocompatibility increases the tolerability and minimizes unwanted side effects, such as thrombus formation. Therefore, during the development of new blood-contacting medical devices, not only the mechanical and chemical characteristics should play an important role, but also the hemocompatibility. Furthermore, to prove the safety and reliability of new products, hemocompatibility analyses should include appropriate references and follow the ISO 10993-4 standard.

Acute coronary syndrome (ACS) remains a major challenge in clinical practice, requiring rapid and effective antithrombotic treatment to mitigate adverse ischemic events while minimizing the risk of bleeding. In recent years, results from several clinical trials addressing this issue through various approaches have substantially improved the treatment landscape for patients presenting with ACS. The emergence of new, potent P2Y12 inhibitors has significantly enhanced thrombotic risk reduction and different strategies for de-escalating and shortening dual antiplatelet therapy (DAPT) have demonstrated promising outcomes in reducing bleeding rates. Furthermore, data from ongoing trials focusing on novel therapeutic agents and investigating alternative treatment strategies to optimize outcomes for ACS patients are expected in the next few years. In this review, we summarize the current knowledge and emphasize the critical role of individualized treatment approaches tailored to patient-specific risk factors and individual clinical scenarios.

Despite substantial advances in stent technology, ISR remains the primary cause of target lesion failure after PCI. The available evidence supports the use of DCB angioplasty and DES implantation as first-line therapies for ISR. Nonetheless, the choice between DES and DCB should be individualized based on clinical, anatomical, and technical factors. In this regard, intravascular imaging with IVUS and OCT can be useful for identifying the primary mechanisms leading to ISR and guiding the interventional strategy during PCI. Moreover, emerging combined approaches employing lesion modification with cutting/scoring balloons, intravascular lithotripsy, rotational atherectomy, or excimer laser in association with DCB or DES can be advantageous in the treatment of specific patterns of ISR. Further high-quality data are needed to define the differential effectiveness and safety of contemporary DCBs and DESs, the long-term clinical outcomes, and whether there are preferential clinical and anatomic conditions for the use of one device over the other.

This product is suitable for patients with primary early to moderate open-angle glaucoma who are unable to tolerate or are unsuitable for traditional filtering surgery, and who, under static gonioscopy, have fully open angles, have had inadequate response or are intolerant to medication alone, and for whom angle laser therapy cannot control disease progression or is deemed inappropriate by the physician. It is also intended for patients who cannot undergo or are ineligible for angle laser therapy, and who require intraocular pressure (IOP) reduction in conjunction with cataract surgery.

Despite the abundance of research examining the effects of coffee, tea, and alcohol on inflammatory diseases, there is a notable absence of conclusive evidence regarding their direct causal influence on circulating inflammatory cytokines. Previous studies have primarily concentrated on established cytokines, neglecting the potential impact of beverage consumption on lesser-studied but equally important cytokines.

The model suggests that inhibiting M-CSF significantly affects the formation of atherosclerotic plaques by altering macrophage behavior and inflammatory responses, while disturbances in cholesterol homeostasis continue to lead to lipid accumulation. This is supported by research indicating M-CSF’s pivotal role in macrophage activation, foam cell creation, and chronic inflammation, which are essential for plaque development and instability. As a result, future therapeutic strategies that aim to target M-CSF and its associated cytokines are proposed to mitigate inflammatory conditions, thus potentially decreasing the risk of adverse events related to atherosclerosis.

Pre-clinical studies have suggested a direct role of vitamin D in the regulation of several pathophysiological pathways, such as endothelial dysfunction and platelet aggregation; moreover, observational data have confirmed the relationship with different conditions, including coronary artery disease, heart failure, and hypertension. Despite the significant evidence available so far, most clinical trials have failed to prove any positive impact of vitamin D supplements on cardiovascular outcomes. This discrepancy indicates the need for further information and knowledge about vitamin D metabolism and its effect on the cardiovascular system, in order to identify those patients who would benefit from vitamin D supplementation.

The relationship between vigorous physical activity (PA) and the development of coronary atherosclerosis has remained less explored for many years. Recently, literature data have focused on coronary atherosclerosis in athletes showing that prevalence is not trivial, that there are differences among various types of sport, and that there are some peculiar features. As a matter of fact, plaque composition in athletes seems to be characterized by calcium rather than soft components. Specific mechanisms through which vigorous PA influences coronary artery disease are not yet fully understood. However, the prevalent calcific nature of coronary plaques in athletes could be related with a trend in a lower cardiovascular event rate.

Indobufen shared the same risk of MACCE but a lower risk of bleeding after PCI versus aspirin from a real-world perspective. Due to the observational nature of the current analysis, future studies are still warranted to further evaluate the efficacy of indobufen based DAPT, especially in patients with ACS.

Replacing aspirin with indobufen in the dual antiplatelet (DAPT) regimen for patients without elevated cardiac troponin after successful drug-eluting stent implantation results in a lower risk of 1-year net clinical outcomes, a difference driven by nonserious bleeding events, according to the randomized OPTION trial.