Researchers at Kumamoto University in Japan have designed an inexpensive and convenient filter that can isolate circulating tumor cells from as little as 1 mL of patient blood. The highly sensitive filter can successfully work in samples containing as few as five tumor cells in 1 mL of blood, and does not require expensive equipment or reagents, unlike certain pre-existing cell capture technologies. The filter may help in developing diagnostic technologies that can aid clinicians in identifying cancer early.
Researchers at Chalmers University of Technology in Sweden and collaborators created a technique to produce fluorescently labeled mRNA, allowing them to track its entry and distribution into cells. Using such molecules could help scientists develop better ways to deliver mRNA therapeutics into the body, potentially playing a vital role in the new wave of mRNA therapies, including vaccines.
Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input. However, there is often a long lag time between an event such as detecting a molecule and the resulting output, because of the time required for cells to transcribe and translate the necessary genes. MIT synthetic biologists have now developed an alternative approach to designing such circuits, which relies exclusively on fast, reversible protein-protein interactions. This means that there's no waiting for genes to be transcribed or translated into proteins, so circuits can be turned on much faster -- within seconds.
The new skin is equipped with artificial sweat ducts that resemble pores in human skin and that have been etched through the material’s ultrathin layers. This ensures that sweat can escape through the electronic skin avoiding damaging and deteriorating the wearable skin.
It’s stretchable, like a band-aid, waterproof, and long lasting. In today’s Medical Moment, how this small patch may soon take the place of invasive health monitors. For many diabetics, daily monitoring of blood sugar means a finger prick. But what if there was a better way?
The use of lateral flow testing is increasing, and for societies to get maximum benefits from it, it has to go digital. The FDA knows this and has recently mandated that any new lateral flow solution must contain a digital component.
CDC teamed up with experts at the University of Utah School of Medicine to estimate that treating six antibiotic resistance threats contribute to more than $4.6 billion in health care costs annually. Partnerships like this help CDC gain a better understanding of the impact of antibiotic resistance in healthcare, help clinicians target infection control practices, and support healthcare decision makers to make informed choices that improve patient safety. Cost estimates can help guide actions needed to prevent resistant infections.
Scientists at Johannes Gutenberg University Mainz (JGU) have developed a novel type of implantable sensor which can be operated in the body for several months. The sensor is based on color-stable gold nanoparticles that are modified with receptors for specific molecules. Embedded into an artificial polymeric tissue, the nanogold is implanted under the skin where it reports changes in drug concentrations by changing its color.
Similar to smartphone tech that detects low air quality, this microchip would pick up the coronavirus.
What Apple has proven across the last few years is that the data its watch gathers can make a difference. But what’s different about the latest Stanford research is that it shows not only that Apple Watch can detect health problems, but also that it enables pretty much the same quality of heart health data you’ll pick up when visiting a clinic.
Ninety percent of consumers would use an at-home COVID-19 test, including half who would use a test at least once per month. Of those surveyed, 75% would be willing to anonymously share their results with local public health officials, and 57% would be at least somewhat willing to share results with their names attached.
Rapid diagnosis is critical for the treatment and prevention of diseases. An advanced nanomaterial‐based biosensing platform that detects COVID‐19 antibodies within seconds is reported. The biosensing platform is created by 3D nanoprinting of three‐dimensional electrodes, coating the electrodes by nanoflakes of reduced‐graphene‐oxide (rGO), and immobilizing specific viral antigens on the rGO nanoflakes. The electrode is then integrated with a microfluidic device and used in a standard electrochemical cell.
The new patch is a product of two pioneering efforts in the UC San Diego Center for Wearable Sensors, for which Wang serves as director. Wang's lab has been developing wearables capable of monitoring multiple signals simultaneously—chemical, physical and electrophysiological—in the body. And in the lab of UC San Diego nanoengineering professor Sheng Xu, researchers have been developing soft, stretchy electronic skin patches that can monitor blood pressure deep inside the body. By joining forces, the researchers created the first flexible, stretchable wearable device that combines chemical sensing (glucose, lactate, alcohol and caffeine) with blood pressure monitoring.
The California Institute of Technology is working on an electronic skin, a sensor-filled sticker, that can turn human sweat into energy enough to power basic devices like heart-rate sensors, glucose-level trackers, or even a low-energy Bluetooth radio. These stickers work by harvesting ‘lactate’ from the sweat we produce. The lactate is absorbed by the electronic skin’s fuel cells – which are made from carbon nanotubes that host a platinum/cobalt catalyst and an enzyme that uses oxygen in the air to break down the lactate into water and a substance called pyruvate. CalTech’s researchers say these stickers can generate a continuous stream of energy (as much as “several milliwatts per square centimeter”), making it enough to offset the need for a battery, which the technology hopes to eventually replace.
Cette innovation pourrait bien permettre aux salariés de retourner au travail : la MedTech Grapheal met au point un test qui, grâce au graphène polymère, détecte le virus en cinq minutes. Les résultats du test arrivant directement sur le smartphone de l’utilisateur.
Diagnostic technology has evolved over the years. Advancements in laboratory science, instrumentation and analysis have led to the introduction of more advanced technologies such as molecular biology, DNA technology, molecular chemistry, cell culture technology, bioanalytical techniques, clinical technologies, computer-aided diagnostic procedures and many others. As these technologies are continuously developed, new diagnostic tools are being introduced in the market that will help doctors evaluate various illnesses and diseases.
Scientists at the RMIT University in Melbourne, Australia have announced the development of an artificial skin material that can sense pain, temperature, and pressure. It’s remarkable because it replicates how real skin responds to stimuli, which sends appropriate electric signals through neural pathways to the brain. The technology is slated to allow for life-like transmission of tactile sensations through prosthetic arms and legs, and may even help replace skin grafts with artificial solutions.
Researchers at Caltech have developed a low-cost multiplex test that can rapidly provide three different types of data on COVID-19. The test can detect the presence of SARS-CoV-2, antibodies against the virus (potentially indicating a level of immunity), and inflammatory markers that could indicate the severity of COVID-19. Using blood or saliva, the test can provide a result in as little as 10 minutes. The researchers hope that it could soon be used by people at home to assess their COVID-19 status.
Scientists at Tulane University have reported a new COVID-19 saliva test that uses a smartphone to provide results in as little as 15 minutes. Similar to technology from UC Berkeley that we reported on last week, the new test uses CRISPR technology and does not involve polymerase chain reaction (PCR) that, though accurate, is slow to deliver results. It is purportedly faster, more accurate, and easier to perform that existing gold standard PCR tests, while requiring less equipment and achieving results in minutes rather than days.
Metagenomics applied in a rapid clinical setting was unthinkable just a few years ago but now can be deployed by any hospital with local deployment.
Researchers at Carnegie Mellon University have developed a microfluidic chip that can provide rapid COVID-19 antibody tests. The electrochemical test can detect very low concentrations of antibodies in blood samples, and transmits the results to a smartphone. The test could help to measure patient responses to vaccines and determine if they have been previously exposed to SARS-CoV-2, the virus responsible for COVID-19.
Emulate has unveiled a brain-chip aimed at enhancing neuroinflammatory disease research and drug discovery. According to a press release by emulate, the comprehensive neurovascular unit model emulates features of the human brain and blood-brain barrier.
The technology is doing to the ubiquitous ELISA tests (Enzyme-linked Immunosorbent Assay) what video did to still photography. It provides a continuous stream of snapshots of readings that can be used to view trends of analyte concentrations in near real-time.
These involve answering a daily survey so as to determine whether or not someone is experiencing symptoms related to COVID-19. These also let you know if you've been exposed to someone with symptoms or who has tested positive for COVID-19.
This home sample collection kit can be purchased online or in a store without a prescription. It is intended to enable users to access information about their COVID-19 infection status that could aid with determining if self-isolation (quarantine) is appropriate and to assist with health care decisions after discussion with a health care professional.
Moderna is using a Roche antibody test in clinical trials of its Covid-19 vaccine. The test can measure the antibodies created through vaccination, offering a window into how long protection lasts.
Remote monitoring startup BioIntelliSense and Royal Phillips received $2.8 million to test BioIntelliSense’s device for the early detection of Covid-19 symptoms. The startup received FDA clearance for its small, adhesive monitoring device last year.
3D-printed microneedles perforated the round window membrane and aspirated 1 µL of perilymph.