More Than Cell Markers: Understanding Heterogeneous Glial Responses to Implantable Neural Devices
www.frontiersin.org
Oct. 27, 2024, 6:55 p.m.
Key design considerations for biocompatibility, efficacy and longevity of microelectrodes to maintain long-term neuronal recording and stimulation are highly dependent on brain tissue response (Polikov et al., 2005). The functional capacities of a biosensor depend on the number of surrounding neurons in a given radius (50–350 μm) (He et al., 2020). Probe insertions generate inflammatory responses to acute tissue injuries and the introduction of foreign bodies, known as “foreign body response” (FBR). Chronic neuroprosthetic implants in rats at 16 weeks in contrast to 8 weeks have been shown to increase neuronal and dendritic loss, correlate with tau hyperphosphorylation seen in Alzheimer's disease and other tauopathies, and impede regeneration and recording of activity surrounding the device